黏附分子CD44V6与唾液酸化Lewis-X抗原在宫颈癌组织中的表达及意义  

The expression and significance of CD44V6 and Sialyl Lewis-X antigen in human cervical cancer.

作　　者：王祥珍[1] 孙显斌[1] 许燕云[2] 

机构地区：[1]广东医学院附属医院妇产科,湛江524001 [2]广东医学院附属医院病理科,湛江52400

出　　处：《中国实用妇科与产科杂志》2004年第11期670-672,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨黏附分子CD4 4V6与唾液酸化Lewis X(SLeX)抗原在宫颈癌组织中的表达及其意义。方法　 1 994年 1月至 1 999年 1月采用免疫组织化学法 (SP法 )检测CD4 4V6与SLeX在 30例正常宫颈组织及 82例宫颈癌组织中的表达。结果　正常宫颈组织CD4 4V6与SLeX均呈阴性表达。 82例宫颈癌组织中CD4 4V6与SLeX的阳性表达率分别为 6 4 6 %(5 3/ 82 )及 6 3 4 %(5 2 / 82 )。CD4 4V6与SLeX的阳性表达与宫颈癌的病灶大小、临床分期、细胞分化程度、转移及预后有关 (P <0 0 1或P <0 0 5 ) ;与宫颈癌的病理类型及患者年龄无关 (P >0 0 5 )。结论　CD4 4V6与SLeX的表达与宫颈癌的生长、浸润及转移密切相关 ,可作为反映宫颈癌恶性潜能及判断患者预后的新指标。Objective To investigate the expression of CD44V6 and Sialyl Lewis-X antigen(SLe X )in human cervical cancer and explore their clinical significance.Methods The expressions of CD44V6 and SLe X were examined in 30 normal cervical tissues and 82 tissues of human cervical cancer by means of immunohistochemical stain.Results There were no expressions of CD44V6 and SLe X in normal controls,the expression rates of CD44V6 and SLe X in cervical cancer tissues being 64 6%(53 82)and 63 4%(52 82),respectively.The positive rates of CD44V6 and SLe X expressions both were related to the size of the focus,cell differentiation,clinical stages,metastasis and prognosis(P<0 01 or P<0 05),but were not related to the pathologic types and patients' ages(P>0 05,respectively).Conclusion The expressions of CD44V6 and SLe X were closely related to the growth,invasion and metastasis of human cervical cancer.They can be used as the new markers for reflecting the cervical malignancy potential and patients' prognosis.

关 键 词：黏附分子 CD44V6 唾液酸化 Lewis-X抗原 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]