急性白血病Ki-67的表达研究  

Study on the expression of ki-67 in acute leukemia

作　　者：沈悦娣[1] 张卫平[2] 丁伟[3] 王丽君[3] 

机构地区：[1]杭州师范学院附属临床学院,浙江杭州310018 [2]温州市第二人民医院,浙江温州325000 [3]浙江大学医学院附属第一医院,浙江杭州310013

出　　处：《检验医学》2004年第6期544-545,共2页Laboratory Medicine

摘　　要：目的　检测急性白血病Ki 6 7的表达 ,探讨细胞增殖在白血病发生中的作用。方法　运用免疫组织化学技术检测Ki 6 7在 2 5例急性白血病患者骨髓组织切片上的Ki 6 7表达 ,以良性血液病患者作为正常对照组。结果　 2 5例急性白血病Ki 6 7表达水平 [(34.18± 17.2 0 ) % ]明显高于对照组 [(12 .17± 6 .2 3) % ,P <0 .0 1];急性淋巴细胞性白血病的Ki 6 7表达 [(31.19± 14 .2 5 ) % ]与急性非淋巴性白血病 [(36 .2 8± 11.87) % ,P>0 .0 5 ]无差异 ;缓解的白血病患者Ki 6 7水平接近对照组。结论　增殖作用增强可能在白血病发生发展中起重要作用 ,Ki 6 7可作为细胞增殖的良好标志。Objective To study the expression of Ki-67 in acute leukemia cells and to illustrate the role of proliferation in the pathogenesis of leukemia. Methods The expression of Ki-67 in bone marrow was studied by immunohistochemistry in 25 cases with acute leukemia and in 10 cases with benign disease as control. Results The expression of Ki-67 in test group [(34.18±17.20)%] was significantly higher than control group [(12.17±6.23)%, P< 0.01 ]. The expression rate of Ki-67 in ALL was (31.19±14.25)%, while in ANLL was (36.28±11.87)% (P> 0.05 ); The Ki-67 expression in the patients with remission decreased and was similar to the control group. Conclusions Enhancement of proliferation may play an important role in the pathogenesis of leukemia, and Ki-67 may reflect the activity of cells proliferation.

关 键 词：急性白血病 KI-67 表达 骨髓 免疫组织化学 

分 类 号：R733.71[医药卫生—肿瘤]