吗啡依赖性大鼠海马CA_1区NKB细胞的改变  

The Alteration of NKB in CA_1 of Hippocampus in Morphine Dependent Rats

作　　者：周郦楠[1] 王冶[1] 张广新[1] 

机构地区：[1]辽宁中医学院职业技术学院形态教研室,辽宁沈阳110101

出　　处：《解剖与临床》2004年第4期244-246,共3页Anatomy and Clinics

基　　金：辽宁省教育厅资助项目编号 2 0 2 15 3 3 2 4

摘　　要：目的 :观察吗啡依赖性大鼠海马CA1区NKB细胞的变化。方法 :用皮下注射吗啡法建立雄性大鼠吗啡依赖模型。用免疫组织化学和图像分析方法观察大鼠CA1区NKB细胞的变化。结果 :吗啡依赖性大鼠海马CA1区NKB细胞免疫反应减弱 ,与对照组相比差异显著 (P <0 .0 1)。结论 :NKB细胞减少与吗啡依赖性的发生、发展有关。Objective:To investigate the relationship between changes of NKB and morphine dependence in rats.Methods:The morphine dependent model of male rats was made by subcutaneous injection of morphine.The alteration of NKB in the hippocampus CA 1 neuron of the rats were studied by means of immunohistochemical method and micro-image analysis system.Results:The NKB positive reactive product in the experiment group was lower than that in the control group ( P <0.01).Conclusion:NKB may play an important role in maintenance and development of morphine dependence.

关 键 词：吗啡依赖 大鼠 海马CA1区 NKB细胞 免疫反应 

分 类 号：R361[医药卫生—病理学]