双歧杆菌微囊肠溶胶囊的制备  

Preparation of bifidobacterial microencapsules in completely closed capsules

作　　者：韩庆惠 李连会[1] 符岳中 

机构地区：[1]上海新药研究开发中心,上海201203 [2]上海中药创新中心,上海201203

出　　处：《中国新药杂志》2004年第11期1002-1005,共4页Chinese Journal of New Drugs

摘　　要：目的:制备全封闭的双歧杆菌活菌微囊胶囊。方法:采用胶囊肠溶包衣新技术和微囊化技术,将不同的高分子材料用于制备全封闭的双歧杆菌活菌微囊胶囊。结果:微囊和微囊胶囊在模拟人工胃液(pH 1.5-2.0)中处理4h,活菌数分别保持在27.6％和84.4％以上,而在人工肠液中处理30min,微囊全部溶出,释放出活性菌,释放率达90％以上。微囊胶囊在37℃下保存3个月(相当于常温下1年以上),其中的活菌数仍大干109个·g-1。结论:制备的微囊对活性菌有保护作用,有效地提高了活性菌体的耐酸性能,微囊中的茵体仍保持较高的活性且能在微囊中继续增殖。Objective:To prepare bifidobacterial microencapsules in completely closed capsules. Methods:The target capsules were prepared with different high polymers using enteric coating and mi-croencapsulation technologies. Results:After treated with artificial gastric solution (pH 1.5-2.0) for 4h, the viable bifidobacterium in the microencapsules were still more than 27. 6 % , in the completely closed capsules they were still more than 84.4 % . After treated with artificial enteric solution (pH 6.8) for 30 min, the microencapsules have completely disintegrated and the viable organism released into solution were more than 90% of the label amount. After stored below 37℃ for 3 months,the amount of viable bifidobacterium were still >1.0×109·g-1. Conclusion: Microencapsulation has protective effect on viable bifidobaterium and can effectively increase the acid - tolerance ability of bifidobacterium. In microencapsules,bifidobacterium keeps a higher competence and can continuously proliferate.

关 键 词：微囊化 双歧杆菌 肠溶包衣技术 

分 类 号：R944.9[医药卫生—药剂学] R378.2[医药卫生—药学]