产后抑郁症患者血孤啡肽水平初步测定  

Changes of Plasma Orphanin in Patients with Postpartum Depression

作　　者：胡电[1] 古航[2] 洪新如 熊英[1] 曹立萍[1] 侯庆香[1] 章青[1] 

机构地区：[1]第二军医大学长征医院妇产科,200003 [2]长海医院妇产科 [3]福州总院妇产科

出　　处：《中国心理卫生杂志》2004年第6期379-380,共2页Chinese Mental Health Journal

摘　　要：目的 :探讨产后抑郁症患者的血孤啡肽水平。方法 :采用放射免疫法测定 2 5例健康产妇 (对照组 )及 2 4例产后抑郁症妇女 (抑郁组 )血孤啡肽含量。结果 :(1)抑郁组血孤啡肽含量为 (2 7.39± 6 .0 4 ) ng/L ,对照组血孤啡肽含量为 (10 .37± 3.6 5 ) ng/ L ;与对照组相比 ,抑郁组孤啡肽含量显著升高 (P<0 .0 1)。(2 )抑郁组 EPDS评分与孤啡呔含量呈显著正相关 (r=0 .4 99,P<0 .0 5 )。结论 :血孤啡肽与产后抑郁症的发生发展可能有一定关系。Objective:To study the changes of plasma orphanin (OFQ) level in post-partum depression (PPD). Methods:The level of plasma OFQ of 24 patients with post-partum depression (PPD group) and 25 healthy lying-in women (control group) were measured by radioimmunoassay.Results:The level of plasma OFQ in PPD group was 27.39±6.04 ng/L , and that of control group was 10.37±3.65 ng/L,the difference was statistically significant(P<0.01). The level of OFQ was positively correlated to EPDS(P<0.05).Conclusions:The changes of OFQ levels may put impacts on the pathogenesis of the PPD.

关 键 词：孤啡肽 产后抑郁症 对照组 患者 肽含量 发生发展 放射免疫法测定 步测 水平 结论 

分 类 号：R749[医药卫生—神经病学与精神病学] R977[医药卫生—临床医学]