An Improved Method for the Sy nthesis of Optically Active Tomoxetines and Fluoxetines  

作　　者：徐成富 袁承业 

机构地区：[1]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2004年第8期775-778,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (Nos. 20272075 and 20372076).

摘　　要：A chemoenzymatic approach was applied to the preparation of chiral 3-hydroxy-3-arylpropionates and 3-hydroxy-4,4,4-trifluorobutanoate that are potential precursors for certain chiral pharmaceuticals including chiral tomoxetines and fluoxetines.A chemoenzymatic approach was applied to the preparation of chiral 3-hydroxy-3-arylpropionates and 3-hydroxy-4,4,4-trifluorobutanoate that are potential precursors for certain chiral pharmaceuticals including chiral tomoxetines and fluoxetines.

关 键 词：hydroxy-3-arylpropionate 3-hydroxy-4 4 4-trifluorobutanoate Candia rugosa lipase (CRL) tomoxetine FLUOXETINE 

分 类 号：O621[理学—有机化学]