骨关节炎滑膜uPA,uPAR,tPA表达及意义  

Expression and its significance of uPA,uPAR,tPA in osteoarthritis

作　　者：李茂强[1] 史晨辉[1] 李宽新[1] 胡文浩[2] 王永明[1] 刘维钢[1] 董金波[1] 李洪安[2] 

机构地区：[1]新疆石河子大学医学院一附院骨一科,石河子市832000 [2]新疆石河子大学医学院病理教研室

出　　处：《中国矫形外科杂志》2004年第21期1686-1688,共3页Orthopedic Journal of China

摘　　要：目的探讨尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)和组织型纤溶酶原激活物(tPA)在OA的发生发展中的意义。方法采用免疫组化方法检测滑膜组织中uPA,uPAR,tPA的表达。结果40例OA滑膜中阳性表达uPA31例(775%)、uPAR22例(55%)、tPA37例(925%)。10例对照滑膜中阳性表达uPA2例(20%)、uPAR1例(10%)、tPA8例(80%)。阳性表达主要分布在滑膜衬里层细胞。结论uPA系统可能参与介导软骨降解。促进OA的发生发展;而tPA可能与OA关系不密切。Objective:To investigate the significance of urinary type plasminogen activator(uPA),urinary type plasminogen activator receptor(uPAR),tissue type plasminogen activator(tPA) in genesis and development of OA Method:Immunohistochemical analysis technique was used to detect uPA,uPAR,tPA expression in synovial tissues in 40 OA patients and 10 normal indivediuls Result:In synovial membranes of 40 cases of OA the positive staining for uPA 31/40(77 5%),uPAR 22/40(55%),tPA 37/40(92 5%)respectively and in synovial membranes of 10 controls the positive staining for uPA 2/10(20%),uPAR 1/10(10%),tPA 8/10(80%)respectively Conclusion:(1)The uPA system may play an important role in the process of degradation of cartilage extracellular matrices of OA (2)tPA may have no connection with the genesis and development of osteoarthritis

关 键 词：骨关节炎 滑膜 UPA UPAR TPA 

分 类 号：R684[医药卫生—骨科学]