宫颈母细胞性NK细胞淋巴瘤1例并文献复习  

Blastic NK lymphoma of uterine cervix: a case report and review of literature

作　　者：赵敏[1] 螘国铮[2] 邢晓皖[2] 丁敏[2] 王晓秋[2] 赵洋[1] 邹强[1] 

机构地区：[1]合肥市第二人民医院病理科,230011 [2]安徽省立医院病理科,合肥230001

出　　处：《临床与实验病理学杂志》2004年第5期533-536,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的　探讨淋巴母细胞NK细胞淋巴瘤的临床病理表现和免疫表型。方法　对 1例宫颈非B非T具有淋巴母细胞形态的淋巴瘤的临床、病理组织学及免疫表型进行观察并复习文献。结果　患者宫颈接触性出血半月伴早期妊娠 ,宫颈重度糜烂。B超示 :宫颈 2 2mm× 17mm的低回声区 ;外周血WBC 4 3× 10 9/L ;全身浅表淋巴结未触及 ,纵隔无块影 ,皮肤未见病损。行全子宫加双侧附件及盆腔淋巴结清扫术。眼观 :宫颈 6cm× 6cm ,重度糜烂 ;镜下见宫颈组织弥漫分布相对单一的中等大小淋巴样细胞 ,胞质稀少 ,核圆或稍不规则 ,染色质细 ,核仁不明显 ,核分裂象 1～ 2个 /10HPF。主要免疫表型 :CD34+、CD7+、TdT +、CD5 6 +、MPO +。随访 8个月 ,体检无阳性体征 ,外周血无异型细胞 ,未行化疗。结论　发生于宫颈的母细胞性NK细胞淋巴瘤极罕见 ,来自NK细胞的特殊类型 ,具有明确的临床病理实体 ;临床表现为侵袭性过程 ,病变局限于皮肤者预后较好。Purpose To investigate the clinicopathological features and immunophenotype of blastic NK cell lymphoma(BNKL). Methods Clinicohistopathological characteristics and immunophenotype was studied with in a case of non T non B neoplasm with lymphoblast mmorphology. Results A case of 35 year old woman presented with touched bleeding and severe erosion of cervix for fifty days. Ultrasonography revealed a mass 22 mm×17 mm in the cervix. Leukemia was rules out by peripheral blood examination,neither enlargement of lymph nodes nor mediastinal mass and lesion of skin. The patient underwent a total hysterectomy with bilateral salpingo-oophorectomy and adenometomy in pelvis. Grossly the cervix was enlargement of 6 cm×6 cm and severe erosion. Microscopically the cervix showed diffuse proliferation of medium sized lymphoid cell with fine chromatin and indistinct nucleoli. The immunophenotypic profile was CD34+ CD7+ TdT+ MPO+ CD56+. The patient was follow up 6 months with no evidence of disease. Conclusions BNKL of the uterine cervix is very rare. It has been reported recently that LBL derived from NK cell. BNKL represents a distinct clinicopathologic entitiy that pursures an aggressive clinical course. Skin BNKL have a better prognosis.

关 键 词：宫颈母细胞性NK细胞淋巴瘤 宫颈肿瘤 病理组织学 免疫表型 

分 类 号：R737.33[医药卫生—肿瘤]