紫杉醇同期放疗化疗与PF方案诱导化疗加局部放疗治疗晚期鼻咽癌近期疗效比较  

Comparison study of concurrent paclitaxel versus PF induced chem otherapy in combination with radiotherapy for treatment of locally advanced nasopharyngeal carcinoma

作　　者：曾子君[1] 李伟雄[1] 陈应瑞[1] 

机构地区：[1]广东省人民医院肿瘤中心放疗科,广东广州510080

出　　处：《实用肿瘤杂志》2004年第6期472-474,共3页Journal of Practical Oncology

摘　　要：目的　比较紫杉醇同期放疗、化疗与 PF方案诱导化疗 +局部放疗治疗晚期鼻咽癌的临床疗效和毒副作用。方法　 72例局部晚期鼻咽癌患者随机分为两组 ,一组 36例为紫杉醇同期放疗 +化疗 (紫杉醇组 ) ,另一组 36例为 PF(DDP,5 - FU )方案诱导化疗 1～ 2个疗程后加放疗 (PF组 )。结果　两组在半量 (40 Gy)放疗结束时鼻咽病灶有效率 (PR+CR)分别为 72 .2 %和 6 9.4 % (P >0 .0 5 ) ;颈部转移灶有效率 (PR+CR)分别为 72 .2 %和 75 .0 %(P>0 .0 5 ) ;全量放疗结束时鼻咽病灶有效率 (PR+CR)分别为 97.2 %和 94 .4 % (P>0 .0 5 ) ;颈部转移灶有效率(PR+CR)分别为 97.2 %和 97.4 % (P>0 .0 5 ) ;放疗毒副作用所致恶心呕吐、口腔黏膜反应和骨髓抑制等差异有显著性 (P<0 .0 5 )。结论　紫杉醇同期放疗、化疗与 PF方案诱导化疗 +局部放疗晚期鼻咽癌局部控制率相近 ,但前者毒副作用较轻。Objective To compare the efficacy and t ox icity of concurrent weekly paclitaxel versus PF(DDP plus 5-FU) induced chemothe rapy in combination with radiotherapy in the treatment of locally advanced nasop haryngeal carcinoma.Methods A total of 72 patients with locally advanced nasopharyngeal carcinomadiagnosed pathologically were randomly divided into two groups. In paclitaxel group 36 patients received concurrent paclitaxel ; in PF group 36 patients received one or two courses of PF (cisplatin, 5-FU) f ollowed by radiotherapy.Results The response rates (PR+CR) to n asopharyngeal lesions were 72.2%and 69.4% in paclitaxel group and PF group, resp ectively (P>0.05) and the response rates (PR+CR) to neck nodes were 72.2% an d75.0%,respectively (P>0.05) when half dose of radiation (40Gy) was given. A fter the whole radiotherapy ended,the response rates (PR+CR) to nasopharyngeal l esions were 97.2% and 94.4%, respectively (P>0.05) and theresponse rates (PR+CR) to neck nodes were 97.2% and 97.4%, respectively (P>0.05). There was no rem arkable difference of the efficacy between the two groups. The main toxicities i ncluding vomiting, mucositis and myelosuppression occurred more frequently in th e PF group (P<0.05).Conclusion The efficacy of concurrent w eekly paclitaxel and PF-induced chemotherapy in combination with radiotherapy f or locally advanced nasopharyngeal carcinoma is same, but the side effect of the former may be milder.

关 键 词：鼻咽肿瘤/放射疗法 鼻咽肿瘤/药物疗法 紫杉醇/治疗应用 顺铂/治疗应用 氟尿嘧啶/治疗应用 药物疗法 联合 随机对照试验 

分 类 号：R739.63[医药卫生—肿瘤]