心肺复苏犬血TNF及ET含量变化的实验研究  

Experimental Study on the Change of ET and TNF Contents in Sera of Dogs during Cardiopulmonary Resuscitation

作　　者：王永进[1] 杨兴易[2] 许永华[2] 赵良[2] 林兆奋[2] 

机构地区：[1]白求恩国际和平医院急诊科,河北石家庄050082 [2]第二军医大学长征医院急救科,上海200003

出　　处：《中国误诊学杂志》2004年第12期1977-1978,共2页Chinese Journal of Misdiagnostics

摘　　要：目的 :探讨复苏犬血肿瘤坏死因子 (TNF)和内皮素 (ET)在复苏前后含量的变化规律及意义。方法 :电击致犬室颤 ,15 min后行标准复苏 ,测量心脏停跳 15 min,复苏后 0 .5 h、2 h、4 h血 TNF及 ET的含量。结果 :与正常组相比 ,心脏停跳 15 min时 ,血 TNF含量即显著升高 (P<0 .0 1) ,复苏后 30 min,血 ET含量亦明显升高 (P<0 .0 1) ,TNF及ET含量于复苏后 2 h达最高 ;各实验组与相应对照组相比与上述结果相似。结论 :复苏前后血 ET、TNF含量变化可能是机体在急剧缺血再灌注后出现的一种强烈的自身应激调节机制 。Objective:To compare the levels of TNF and ET in sera of dogs before and after cardiopulmonary resuscitation and to analyze its clinical significance.Methods:Ventricular fibrillation/cardiac arrest (CA) models were made by electrical shock and the standard cardiopulmonary resuscitation was performed 15 minutes later. ET and TNF contents in sera were measured at 15 minutes after CA,0.5 h, 2 h, 4 h after-resuscitation respectively. Results:TNF content increased markedly(P<0.01) compared with that of the normal group at 15 minutes after CA. At 0.5 h after resuscitation, ET content increased too(P<0.01). Both reached peak values at 2 h after resuscitation. The phenomenoa were almost the same in each experimental group and its correspondingcontrol group.Conclusion:Changes of TNF and ET levels in sera before and after resuscitation in dogs could be attributed to an intense stress regulating mechanism during ischemia reperfusion,which could play an important role in the pathophysiological process after cardiompulmonary resuscitation.

关 键 词：心肺复苏 内皮索 肿瘤坏死因子 

分 类 号：R654.1[医药卫生—外科学]