市售六种维A酸外用制剂对皮肤累积刺激性的评估  

Evaluation of Cumulative Skin-irritation of Six Commercinlly Available Topical Retinoic Acid Preparations

作　　者：毕志刚[1] 张美华[1] 苏忠兰[1] 刘国红[1] 张晓军[1] 娄冬华[1] 赵辨[1] 

机构地区：[1]南京医科大学第一附属医院皮肤科,210029

出　　处：《中华皮肤科杂志》2003年第12期705-707,共3页Chinese Journal of Dermatology

摘　　要：目的评价常用维A酸外用制剂对皮肤的累积刺激作用。方法采用随机对照、双盲法将试验药与对照药分为7组。对受试者每周每种药品进行4次24h的斑贴试验和1次72h的斑贴试验观察。共进行3周的观察。结果累积刺激最小的是0.1%阿达帕林凝胶组,累积刺激指数为0.09±0.11,其20d的累积刺激指数为0.09±0.11;累积刺激作用最大的0.1%维A酸霜组为0.59±0.24,2组比较差异有显著性(P<0.001)。0.1%阿达帕林凝胶的累积刺激指数还明显小于0.025%维A酸霜组(0.41±0.22)和0.05%维A酸霜组(0.25±0.22)。结论国内外常用的治疗痤疮的维A酸外用制剂是安全的。外用阿达帕林凝胶的刺激作用不但明显小于0.1%维A酸霜,也小于0.05%维A酸霜。Objective To evaluate the cumulative irritative effect of topical retinoic acid preparations on normal skin.Methods A randomlized,doubled blind,placebo-controlled clinical trial was carried out with7groups for6tested preparations.All subjects were patch tested with each preparation for24hours on Monday to Thursday,and for72hours on Friday.The patch tests were performed for3consecutive weeks.Results The minimal cumulative irritative effects were found in Group G treated with0.1%adapalene gel,with a cumulative irritative index of0.09±0.11in20days.The cumulative irritative index was significantly lower in Group G than that in Group B treated with0.1%retinoic acid(Diweishuang誖)(0.59±0.24),or in0.025%retinoic acid(Diweishuang誖)(0.41±0.22),or in0.05%retinoic acid(VITAMIN誖Cream)(0.25±0.22).Conclusion Adapalene,the third generation of retinoic acid,is characterized by lower irritative ef-fects in comparison to the first generation of topical retinoic acid agents.

关 键 词：维A酸霜 外用制剂 刺激作用 皮肤 市售 治疗 观察 刺激指数 结论 最大 

分 类 号：R965[医药卫生—药理学]