缺血性中风病人红细胞膜唾液酸与膜微粘度的研究  

Sialic acid and microviscosity of erythrocyte membrane in ischemic stroke

作　　者：冷贵生[1] 王忠兰[1] 郭述苏[1] 樊红[1] 杜燕[1] 

机构地区：[1]济南军区总医院,250031

出　　处：《临床神经病学杂志》1993年第4期218-219,共2页Journal of Clinical Neurology

摘　　要：通过检测53例脑梗塞和20例健康对照者的红细胞膜微粘度及膜唾液酸,发现脑梗塞患者红细胞膜微粘度显著高于对照者,红细胞膜唾液酸显著低于对照者,且患者组红细胞膜微粘度与膜唾液酸含量呈显著负相关,提示红细胞膜唾液酸含量变化对缺血性中风的发生和发展具有一定的意义。The microviscosity and sialic acid level of erythtocyte membrane from 53 ischemic stroke patients and 20 controls were measured by fluorescent polarization and biochemical method. Sialic acid level of red blood cell in stroke patients was significantly higher than in controls, but the microviscosity was significantly lower than in controls, furthermore, the microviscosity of erythrocyte membrane in ischemic stroke patients was inversely correlated with sialic acid level. These findings suggest that sialic acid changes of erythrocyte membrane play a role in developing ischemic stroke.

关 键 词：膜微粘度 唾液酸 脑栓塞 红细胞膜 

分 类 号：R743.33[医药卫生—神经病学与精神病学]