紫杉醇同步放疗对老年晚期非小细胞肺癌的治疗  

Concurrent Weekly Paclitaxel and Radiotherapy for Elderly Patients with Advanced Non-small Cell Lung Cancer

作　　者：鲁培[1] 王留兴[1] 王丽萍[1] 高国谦[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052

出　　处：《中国误诊学杂志》2004年第8期1204-1206,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :观察紫杉醇并同步放疗治疗老年晚期非小细胞肺癌的近期疗效及毒副反应。方法 :32例 6 5岁以上一般状况较差的晚期非小细胞肺癌 32例 ,给予 6 0 Coγ线或加速器 X线常规外照射 ,1.8～ 2 Gy/次 ,5次 /周 ,5 6～ 6 0 Gy/6～ 7周。放疗前紫杉醇 6 0 mg/m2 ,3h静滴 ,每周 1次。结果 :初治患者 RR81% ,复治患者 RR4 5 .5 % ,ORR6 8.8%。毒性反应 :食道炎 5 9.4 % ,白细胞减少 5 9.4 % ,放射性肺炎 2 8.1%。无治疗相关性死亡。结论 :紫杉醇同步放疗治疗一般情况较差的老年 NSCL C,近期疗效满意 ,毒性可以接受。Objectives:To evaluate the therapeutic significance of concurrent paclitaxel and radiotherapy for elderly patients with advanced NSCLC. Methods:Elderly (≥65y) Patients with advanced,inoperable NSCLC received either cobalt-60 gamma rays or the linear accelerator X rays at split-course schedule with the total dose of 56~60 Gy/6~7 weeks and Paclitaxel,60 mg/m 2,administered on the first day of each radiotherapy week.Results:Of 32 patients enrolled,the objective response occurred in 17 (81%)of chemo-nave patients and 5(45.5%)of the others,the overall response rate was 68.8%. The more frequent toxicities were esophagitis,leukopenia and pneumonitis (59.4%,59.4% and 28.1%,respectively). No serious toxicity and treatment related death occurred.Conclusions:This regiment was well-tolerated and effective in elderly patients with advanced NSCLC.

关 键 词：紫杉酚/治疗应用 放射疗法 癌 非小细胞肺/治疗 肺肿瘤/治疗 

分 类 号：R734.205[医药卫生—肿瘤]