环糊精与鱼腥草素钠相互作用的电喷雾质谱法和毛细管电泳法研究比较  

作　　者：陈建新[1] 陈杖榴[1] 曾振灵[1] 贺丽苹[2] 马安德 

机构地区：[1]华南农业大学兽医学院，广东广州510642 [2]华南农业大学测试中心，广东广州510642 [3]第一军医大学分析测试中心，广东广州510515

出　　处：《质谱学报》2004年第B10期47-48,共2页Journal of Chinese Mass Spectrometry Society

摘　　要：Noncovalent inclusion complex between β-cyclodextrin and sodium houttuyfonate were studied by electrospray ionization mass spectrometry (ESI-MS) and capillary electrophoresis (CE). It was observed that β-cyclodextrin and sodium houttuyfonate integrated at a radio of 1 : 1 by ESI-MS in the negative-ion mode. The relative intensity of the inclusion complex ion was 18% compared with β-cyclodextrin ion, and 20% compared with houttuyfonate ion, respectively. The results indicated that the inclusion complex was considerable steady in the gas phase. The mobilities of houttuyfonate were measured in solution with different concentration of β-cyclodextrin by capillary electrophoresis, and the logarithm of inclusion constant obtained from mobilities were 3. 845, indicated that the interaction of the houttuyfonate and β-cyclodextrin is strong.

关 键 词：环糊精 鱼腥草素钠 相互作用 电喷雾质谱法 毛细管电泳法 包络材料 药物制剂 

分 类 号：O636.12[理学—高分子化学] R94[理学—化学]