原发性肝癌组织中肥大细胞计数的免疫组化研究  

Immunohistochemical study on mast cell count(MCC) in primary hepatocarcinoma tissues

作　　者：黄江生[1] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011

出　　处：《中国现代医学杂志》2004年第21期58-60,共3页China Journal of Modern Medicine

摘　　要：目的研究原发性肝癌(PHC)及其癌旁肝组织中肥大细胞计数(MCC)及其临床病理意义。方法47例PHC手术切除标本经10%中性福尔马林固定后作石蜡包埋切片,MCC染色为常规免疫组化法。结果PHC组织中MMCC均值明显高于其癌旁肝组织(P<0.01),中重度肝硬化、有转移、有癌栓及弥漫结节型PHC病例MCC均值均明显高于无或轻度肝硬化、无转移、无癌栓PHC病例,均差异有显著性(P<0.05);MCC与PHC其他临床病理特征无明显关系(P>0.05)。结论MCC可能是评估PHC生物学行为和预后的重要参数之一。Objective:To study the MCC and detect it' s clinicopathological significances in primary hepatocarci-noma(PHC)tissues.Methods:Immunohistochemical method was used for MCC on the formalin-fixed and routinely paraffin-embedded sections of47cases with PHC and pericancerous liver tissues.Results:The MCC was signifi-cantly higher in PHC tissues than that of pericancerous liver tissues(p<0.01).The MCC was significantly higher in the cases of middly-to-serenely liver cirrhosis,with-metastasis,with-cancer emboli,or spreaded than that in the ones of without-or-mild liver cirrhosis,without-metastasis,without-cancer emboli,in the PHC.Conclusions:MCC may be one of important targests for evulating the biological behaviors and prognosis of PHC.

关 键 词：原发性肝癌 肥大细胞 计数 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]