NIDDM患者肝素后血浆LPL和HEL活性变化  

THE CHANGES OF POSTHEPARIN PLASMA LIPOPROTEIN LIPASE AND HEPATIC ENDOTHELIAL LIPASE ACTIVITIES IN PATIENTS WITH NIDDM

作　　者：钟海新 严棠 陈玉驹[1] 

机构地区：[1]孙逸仙纪念医院内科内分泌室

出　　处：《中山大学学报（医学科学版）》1993年第3期217-221,共5页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：本文研究91例非胰岛素依赖型糖尿病(NIDDM)患者(合并冠心病者30例),肝素后血浆脂蛋白脂酶(LPL)和肝内皮细胞脂酶(HEL)活性变化及其与血清高密度脂蛋白胆固醇(HDLch)水平的相关性,并对其可能在冠心病(CHD)中的作用进行初步探讨。以71例性别、年龄、体重指数(BMI)相匹配而无CHD的非糖尿病人作为对照组。结果表明:病人LPL活性低于对照组,HEL活性高于对照组(LPL:1.20±O.65 VS2.20土0.68u MFFA/mL/h,p<0.001;HRL:4.46±1.94 Vs2.36±09 u MFFA/mL/h,P<0.001。LPL活性与HDLch水平呈正相关(γ=0.278,P<0.01),而“[HEL活性与HDLCh水平呈负相关(γ=-0.521,P<0.001)。此外,男、女性病人合并有CHD组的HEL活性明显高于无CHD组;女性病人合并CHD组的LPL活性显著低于无CHD组,但男性病人合并CHD组的LPL活性无显著性降低。结合有关文献讨论LPL和HEL在脂蛋白代谢方面的作用。This is a crossectional study on changes of postheparin plasma lipoprotein lipase (LPL) and hepatic endothelial lipase (HEL) activities, its correlation with serum high density lipoprotein cholesterol (HDLch) levels, and possible relationship with CHD in a group of 94 NIDDM patients in whom 30 were found to be complicated with CHD, 71 cases apparently healthy nondiabetic subjects matched for sex and age and BMI and without CHD were taken for control. It was found that plasma LPL activity was much lower and HEL activity higher in the diabetic group than in the non-diabetic control (LPL: 1.20±0.65 vs 2.20±0.68μMFFA/ml/h, P<0.001); HEL: 4.46±1.94 vs 2.36±1.09μ MFFA/ml/h, P<0.001). Plasma LPL activity showed a positive correlation with serum-levels of HDLch (r= 0.278, P<0.01), whereas plasma HEL activity was negatively correlated with serum levels of HDLch (r= -0.521, P<0.001)- Furthermore, the increase of plasma HEL activity was more pronounced in both male and female diabetics complicated with CHD than in those patients without. The decrease of plasma LPL activity was more marked in female diabetics complicated with CHD than in those without, while in male patients the decrease of plasma LPL activity was less significant. Together with a review of relevant literature, the role of LPL and HEL in the metabolism of lipoproteins was discussed.

关 键 词：LPL CHD HEL 对照组 NIDDM 患者 活性 降低 研究 BMI 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]