四逆汤对缺血心肌NBF,OFR浓度SOD活性及MDA含量的影响  

EXPERIMENTAL STUDY OF THE PROTECTIVE EFFECTS OF SINI DECOCTION ON ISCHEMIC MYOCARDIUM

作　　者：吴伟康[1] 侯灿[1] 罗汉川[1] 卢景雰[2] 杨正红[2] 

机构地区：[1]中山医科大学病理生理学教研室中医理论研究室 [2]北京医科大学天然药物与仿生药物国家重点实验室

出　　处：《中山大学学报（医学科学版）》1993年第4期292-295,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家中医药管理局重点课题

摘　　要：从自由基角度在小鼠垂体后叶素(Pit)性心肌缺血模型上探讨了四逆汤保护缺血心肌的可能性,结果表明四逆汤显著降低缺血心肌的OFR浓度和MDA含量,显著增加心肌NBF和SOD活性,提示四逆汤可显著减少自由基损伤性因子,改善缺血心肌的灌流,增强自由基清除能力,该方剂可能对缺血心肌产生积极的保护作用。Protective effects of Sini decoction (SD,四逆汤) on myocardium from ischemic injury were studied in pituitrin-induced myocardial ischemic mice. Results indicate that SD significantly decreased the concentration of OFR, the content of MDA, and increased NBF and activity of SOD in ischemic myocardium. These results suggest that SD can significantly improve the blood supply of ischemic myocardium, reduce the damaging factors of free radical and streghten myocardial defense mechanism. We conclude that the decoction may have a protective effect on ischemic myocardium.

关 键 词：缺血心肌 四逆汤 SOD活性 垂体后叶 心肌缺血 自由基清除 灌流 增强 降低 因子 

分 类 号：R542[医药卫生—心血管疾病] R541[医药卫生—内科学]