血清乙酰胆碱受体抗体、突触前膜抗体和胸腺瘤相关抗体与重症肌无力发病关系的研究  

A Study on Correlation of Myasthenia Gravis with Seral Acetylcholine Receptor Antibody,Pre-synaptic Membrane Antibody, and Citric Acid Extract Antibody

作　　者：高波廷[1] 杨明山[1] 刘锡民[1] 徐金枝[1] 曹学兵[1] 

机构地区：[1]同济医科大学附属同济医院神经科

出　　处：《中国神经免疫学和神经病学杂志》1994年第1期36-40,共5页Chinese Journal of Neuroimmunology and Neurology

摘　　要：本研究用ＥＬＩＳＡ法同步、动态地检测了２８５例ＭＧ患者血清乙酰胆碱受体抗体（ＡｃｈＲａｂ）、突触前膜抗体（ＰｓＭａｂ）和胸腺瘤相关抗体（ＣＡＥａｂ）的变化。实验结果表明，ＭＧ患者体内增高的ＡｃｈＲａｂ是ＭＧ发病的主要体液因素。部分血清ＡｃｈＲａｂ阴性ＭＧ患者（１７．５％）的发病，可能与血清ＰｓＭａｂ异常有关。另一部分血清ＡｃｈＲａｂ和ＰｓＭａｂ均异常的ＭＧ患者（１２．６％），则可能同时存在骨骼肌神经肌接头突触前和突触后的损害。血清ＣＡＥａｂ测定在辅助诊断胸腺瘤方面具有高度的灵敏度和特异性，可作为临床早期诊断胸腺瘤的过筛检查。In this report,acetylcholine receptor antibody (AchRab),pre-synaptic membrane antibody(PsMab),and thymomaassociated antibody or citric acid extract antibody(CAEab) in sera of 285 patients with myasthenia gravis (MG) were dynamically detected with ELISA.The results showed that the increased seral AchRab might be a major factor in pathogenesis of MG.For the kind of seronegative MG patients (17.5%),seral PsMab may play an important role in etiology and pathogenesis of MG.There may be both post-synaptic and presynaptic damages in the patients whose seral AchRab and PsMab titers are increased. The detection of serum CAEab with ELISA possesses high sensitivity and specificity in discover ing thymoma. This serological assay may be used as a screen test for diagnosing thymoma early in neurological bedside.

关 键 词：胸腺瘤 血清 患者 突触 前膜 相关抗体 乙酰胆碱受体抗体 特异性 实验结果 动态 

分 类 号：R746.1[医药卫生—神经病学与精神病学] R736.3[医药卫生—临床医学]