同时测定血清和脑脊液NANA含量对脑梗塞及多发性硬化症的临床诊断价值  

Diagnostic Value of NANA in Serum and CSF for Cerbral Infarction and Multiple Sclerosis

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作  者:元小冬[1] 米振洲[1] 安心[1] 袁建新[1] 袁锦楣[1] 

机构地区:[1]唐山开滦矿务局总医院神经科,北京医科大学第一医院神经科

出  处:《中国神经免疫学和神经病学杂志》1995年第2期105-107,共3页Chinese Journal of Neuroimmunology and Neurology

摘  要:同时测定血清和脑脊液NANA含量对脑梗塞及多发性硬化症的临床诊断价值元小冬,米振洲,安心,袁建新,袁锦楣(唐山开滦矿务局总医院神经科,唐山063000)N-乙酰神经氨酸(NANA)做为神经节苷脂的重要组成成分,参与多种神经活动,但它在缺血性和原发性脱...AbstractThe levels of N-acetylneuraminic acid(NANA)in serum and cerebrospinal fluid(CSF)were measured in 31 patients with cerebral infarctions (CI),26 cases with multiple sclerosis (MS)and 30 controls.Serum NANA level in patients with MS was significantly higher than that in controls,but there was no significant difference between patient with CI and controls.CSF NANA level was significantly higher in both MS and CI groups than that in controls.The ratio of NANA concentrations(serum/CSF)did not show any significant changes among three groups. Multivariate correlation analysis showed that CSF glucose concentration in patients with CI had direct positive correlation with CSF concentration of NANA,but not in patients with MS.Thses results suggested that the possible mechanism of increased CSF NANA concentration between patients with MS and CI were different.

关 键 词:多发性硬化症 脑脊液 脑梗塞 血清 临床诊断 含量 同时测定 神经活动 组成成分 神经节苷脂 

分 类 号:R744.51[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]

 

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