细胞的死亡和川楝素的诱发凋亡作用  

Cell death and apoptosis-induced effect of toosendanin

作　　者：施玉樑[1] 汤勉芝[1] 

机构地区：[1]中国科学院上海生命科学研究院,上海200031

出　　处：《中国神经科学杂志》2004年第6期461-465,共5页

基　　金：国家重点基础研究规划"脑功能和脑重大疾病的基础研究 (G 19990 5 40 0 0 )" ;自然科学基金 (3 0 170 3 0 2 ) ;上海市基础研究重点项目 (0 2JC14 0 11)

摘　　要：细胞死亡是生物有机体正常发育和维持稳态过程中的一个基本生命现象。凋亡和坏死是细胞死亡的两种方式 ,它们不同但又难以截然分开。抑制肿瘤细胞无限增殖 ,使之凋亡是探索抗癌药的重要方向。川楝素对多种肿瘤细胞的抑制增殖作用及诱发凋亡作用表明它可能是具有这种功效的抗癌药物候选者。Cell death plays an important role in the biological process of development, and homeostasis of multicellular organism. It could be divided into two forms, cell apoptosis and necrosis, which are different but hard to be distinguished completely. One of the major indexes of a potent effective anti-cancer drug lies in that it can inhibit cancer cell growth, and subsequently induce apoptosis. It was found that toosendanin could inhibit cell growth, then induce apoptosis in various cancer cell lines, which indicate that toosendanin could serve as a candidate anti-cancer drug.

关 键 词：细胞死亡 凋亡 川楝素 抗肿瘤 

分 类 号：R363[医药卫生—病理学]