Xa21转基因大米对大鼠致畸作用的实验研究  

Study on the teratogenicity effects of genetically modified rice with Xa21 on rats

作　　者：李英华[1] 朴建华[1] 卓勤[1] 陈小萍[1] 毛德倩[1] 杨丽琛[1] 杨晓光[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050

出　　处：《卫生研究》2004年第6期710-712,共3页Journal of Hygiene Research

基　　金：国家科技部 973计划 (No .2 0 0 1CB1 0 90 0 7) ;国家科技部863计划 (No.AA2 2 1 2 2 91 ) ;科技部国家转基因植物研究与产业化专项(No .J0 0 C 0 0 3)

摘　　要：目的　观察Xa2 1转基因大米对大鼠胚胎生长、发育的影响。方法　将初断乳Wistar大鼠按雌雄分别随机分为 4组 :转基因大米组、非转基因大米组、AIN93G对照组和敌枯双阳性对照组。单笼喂养 ,饲相应鼠料 ,喂满 90天 ,雌雄合笼。观察母鼠和胎鼠的生长发育情况。结果　转基因大米组孕鼠增重、活胎体重、身长、尾长均显著高于阳性对照组 ,而死胎数、吸收胎数、畸形率 (外观、内脏、骨骼 )均显著低于阳性对照组。转基因大米组与非转基因大米组、AIN93G对照组相比 ,所有观察指标均无统计学差异。结论　转Xa2 1基因大米与非转基因大米相比 ,对大鼠受孕率、胚胎生长发育无显著性差异。Objective To observe the effects of genetically modified rice with Xa21on the development of rat embryos.Methods According to sex,weanling rats were divided into four groups:transgenic rice group,non-transgenic rice group,AIN93G negative control group and MATDA positive control group.The rats were fed with corresponding food for 90 days and mated.The development of maternal rats and embryos were observed.Results The body weight gain of pregnant rats and the body weight,body length and tail length of fetal rats in transgenic rice group were significant increased than those in positive control group.The number of death embryos and adsorption embryos,the malformation rate (appearance,viscera,skeleton) in transgenic rice group were lower than those in positive control group.There were no significant difference of all indicators among transgenic rice group,non-transgenic rice group and AIN93G negative control group.Conclusion Compared with the non-transgenic rice,transgenic rice modified with Xa21 gene showed no significant differences in rat pregnant rate and embryo development.

关 键 词：转基因大米 XA21 致畸实验 

分 类 号：R155.5[医药卫生—营养与食品卫生学] Q78[医药卫生—公共卫生与预防医学]