肝硬化门静脉高压症患者肝脏功能性血流量检测的临床意义  

Clinical study on functional hepatic blood flow in cirrhotic patients with portal hypertension

作　　者：潘峥[1] 吴性江[1] 黎介寿[1] 刘放南[1] 李为苏[1] 韩建明[1] 

机构地区：[1]南京军区南京总医院普通外科研究所,210002

出　　处：《中华普通外科杂志》2004年第11期653-655,共3页Chinese Journal of General Surgery

摘　　要：目的探讨肝硬化门静脉高压症患者肝脏血流灌注的改变,评估肝脏储备功能。方法应用彩色多普勒及改进的D山梨醇肝清除率法分别对27例肝硬化门静脉高压症患者及10例正常对照进行肝总血流量(THF)和肝功能性血流量(FHF)的检测。结果对照组THF与FHF分别为(1256±198)mlmin和(1195±243)mlmin,两者比较差异无显著意义;肝硬化门静脉高压症各Child分级患者的THF与FHF和对照组比较差异均有显著意义。8例肝硬化患者经颈静脉肝内门体分流术治疗1周后FHF与术前比较差异有显著意义(529±109比833±166,P<001),肝功能ChildPugh计分也有显著变化(838±192比763±192,P<005);10例患者行门奇断流术后1周FHF与ChildPugh计分与术前比较差异均无显著意义。结论应用彩色多普勒结合改进的D山梨醇肝清除率法测量THF与FHF是可行的。Objective To evaluate hepatic reserve function by investigating changes of functional hepatic blood flow (FHF) and total hepatic blood flow (THF) in cirrhotic patients with portal hypertension Methods FHF and THF were determined by means of modified hepatic clearance of D sorbitol combined with duplex Doppler color sonography in 27 portal hypertensive patients with cirrhosis and 10 healthy volunteers Results FHF evaluated by means of the D sorbitol clearance was reduced in Child′s A, B and C cirrhotics compared to controls, while THF was increased After transjugular intrahepatic portacaval stent shunt in 8 patients a substantial reduction was observed in FHF (529±109 vs 833±166; P <0 01) While after portal azygous disconnection in 10 patients no changes were observed in FHF and Child Pugh scores Conclusions Modified hepatic clearance of D sorbitol and duplex Doppler color sonography in combination is effective in the measurement of FHF and THF

关 键 词：FHF 患者 肝硬化门静脉高压 血流量 CHILD-PUGH 对照组 计分 肝脏功能 清除率 彩色多普勒 

分 类 号：R575.2[医药卫生—消化系统]