^(99)Tc^m-HL91与^(99)Tc^m-MIBI肿瘤阳性显像在肺部肿块诊断中的对比研究  

Comparison of ^(99)Tc^m-HL91 and ^(99)Tc^m-MIBI tumor positive imaging in diagnosis of lung neoplasms

作　　者：邓惠兴[1] 杨爱民[1] 胡国瑛[1] 冉宏德[1] 高信耀[1] 程虎[1] 刘敏[1] 邹保民[1] 

机构地区：[1]西安交通大学第一医院核医学科,陕西西安710061

出　　处：《中国医学影像技术》2004年第11期1757-1760,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的　比较99Tcm HL91和99Tcm MIBI肿瘤阳性显像对肺部单发肿块的诊断效能和影像质量。方法　 5 0例肺部结节或肿块患者 ,分为恶性组和良性组 ,术前分别行99Tcm HL91和99Tcm MIBI早、晚期平面及断层融合显像 ,对显像结果进行对照分析。结果　①定性诊断HL91组的敏感性为 97.3 0 % ( 3 6/3 7例 ) ,特异性为 69.2 3 % ( 9/13例 ) ;MIBI组诊断的敏感性为83 .78% ( 3 1/3 7例 ) ,特异性为 76.92 % ( 10 /13例 )。肺门及纵膈肿大淋巴结使用HL91检测的阳性率为 91.3 0 % ( 2 1/2 3个 ) ;MIBI法为 73 .91% ( 17/2 3个 )。②HL91法断层显像ROC曲线下的面积 ( 0 .95 3± 0 .0 3 4)较MIBI法 ( 0 .85 7± 0 .0 73 )高约 10 % ,以T/N值 1.76为界点HL91诊断的敏感性为 10 0 % ( 3 7/3 7例 ) ,特异性为 84.62 % ( 11/13例 ) ;以 1.66为界点MIBI组诊断的敏感性为 86.49% ( 3 2 /3 7例 ) ,特异性为 76.92 % ( 10 /13例 ) ,以 1.85为界点MIBI组诊断的敏感性为 78.3 8% ( 2 9/3 7例 ) ,特异性为 84.62 % ( 11/13例 )。结论　99Tcm HL91肺部病变亲肿瘤阳性显像在图像质量和诊断性能上均优于99TcmObjective To compare the diagnostic value and imaging quality between()^(99)Tc^m-HL91 and()^(99)Tc^m-MIBI tumor positive imaging about pulmonary neoplasm. Methods Total 50 patients with pulmonary neoplasms examined by spiral CT were selected. All patients were verified by biopsy or surgery, and divided into benign and malignant group. Early and late phase planar and tomography imaging were done in all patients using()^(99)Tc^m-HL91 and()^(99)Tc^m-MIBI. The visualization and half quantitative methods were used to analyze all imaging. Results The sensitivity and specificity of HL91 imaging were 97.3% and 69.23%, respectively, and 83.78% and 76.92% of MIBI. The positivity rates of lymph gland of lung hilus and mediastinal were 91.30% of HL91 and 73.91% of MIBI. The AUC^(ROC) of HL91 tomography imaging was 0.953±(0.034), about 10% higher than MIBI. A threshold (T/N=1.76) was gained from ROC curve of HL91 4h tomography phase and was used to distinguish the character of pulmonary neoplasm,with sensitivity and the specificity of 100% and 84.62%,respectively. Using 1.66 as the threshold of MIBI image, the sensitivity and the specificity were 86.49% and 76.92%, (78.38%) and 84.62% respectively if the threshold of MIBI image was 1.85. Conclusion The diagnosis capability and the imaging quality of()^(99)Tc^m-HL91 are superior to that of()^(99)Tc^m-MIBI. [

关 键 词：肺肿瘤 HL91 MIBI ROC特征曲线 体层摄影术 发射型计算机 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]