P^(16)蛋白和P^(73)蛋白在鼻咽癌中的表达及临床意义  

Clinical Significance of P^(16) and P^(73) Proteins Expression in Nasopharyngeal Carcinoma

作　　者：樊贤超[1] 董晨[2] 陈骏[3] 

机构地区：[1]南京医科大学附属南京第一医院,江苏南京21000 [2]东南大学医学院免疫教研室,江苏南京21000 [3]江苏省肿瘤医院,江苏南京210000

出　　处：《黑龙江医学》2004年第12期892-893,共2页Heilongjiang Medical Journal

摘　　要：目的　探讨鼻咽癌组织中P16 蛋白和P73蛋白的表达及其临床意义。方法　采用免疫组化S -P法 ,检测P16 蛋白和P73蛋白在 4 0例鼻咽癌组织和 2 0例鼻咽癌黏膜慢性炎症组织中的表达情况。结果　 4 0例鼻咽癌组织中P16 蛋白阳性表达率明显低于鼻咽黏膜慢性炎症组织 (P <0 0 5 ) ,而P73蛋白在 4 0例鼻咽癌组织中的表达较鼻咽黏膜慢性炎症组织相比明显增高 (P <0 0 5 )。P16 蛋白和P73蛋白的表达与颈部淋巴结转移、局部区域复发以及远处转移无明显相关 (P >0 0 5 ) ,且P16 蛋白与P73蛋白的表达亦无明显相关。结论　P16 蛋白的低水平表达和P73蛋白的高水平表达可能与鼻咽癌的发生发展有关。Objective To study clinical significance of P 16 and P 73 proteins expression in nasopharyngeal carcinoma. Methods 40 of carcinomatous tissue and 20 of chronic nasopharyngitis patient were studied by means of S-P immunohistochemical stain method for P 16 and P 73 proteins. Results The positive rate of P 16 in carcinomatous group was lower than that in nasopharyngitis group obviously (P<0.05). The positive rate of P 73 in carcinomatous group was higher than that in control group(P<0.05). The positive rates of P 16 and P 73 proteins were not statistically difference among NPC.T.N and clinical stages. Conclusion The low positive expression rate of P 16 and higher rate of P 73 may be related to the process of NPC.

关 键 词：肿瘤学 鼻咽癌 P^16蛋白 P^73蛋白 

分 类 号：R739.63[医药卫生—肿瘤]