联立方程新解法测定复方强的松龙滴鼻液中两组分的含量  

Determination of two components in compound hydrocortisone nasal drops by new vierordt method

作　　者：陈元俊[1] 周金生[1] 卢玉兰[1] 丁川[1] 胡晓添[1] 连劲龙[1] 

机构地区：[1]中国人民解放军第180医院,福建泉州362000

出　　处：《药学实践杂志》2004年第6期331-333,共3页Journal of Pharmaceutical Practice

摘　　要：目的:测定复方强的松龙滴鼻液中醋酸泼尼松龙和马来酸氯苯那敏的含量.方法:采用新Vierordt法,以二组分的最大吸收波长242.5nm和261.5nm为测定波长,以无水乙醇作为空白,不经分离直接测定复方强的松龙滴鼻液中二组分的含量.结果:两组分回归系数分别为0.999 8(1.775 4～17.754μg/mL)和0.999 7(2.656～26.56μg/mL),回收率分别为99.6%,RSD=0.8%;99.7%,RSD=0.6%.αβ＜0.5,Aa+b261.5/βAa+b242.5＞1.2,Aa+b242.5/αAa+b261.5＞1.2,符合要求,结论:本方法简便快速,重现性好,消除了二组分相互干扰,结果满意.Objective: To determinate two components of hydrocortisone acetate and chlorphenamine maleate in compound hydro-cortisone nasal drops. Methods:The components were determinated directly by new Vierordt mothod without separation. The detection wavelengths were 242. 5nm and 261. 5nm. The blank reference was ethanol absolute. Results:The result showed good linear relationship between the concentration and the peak area ratio of the two components. The respective correlation coefficients of hydrocortisone and chlorphenamine maleate were 0. 999 8 in the range of 1. 775 4 μg/mL to 17. 754μg/mL and 0. 999 7 in the range of 2. 656μg/mL to 26. 56μg/mL. Average recovery of hydrocortisone and chlorphenamine maleate were 99. 6% with RSD 0. 8% and 99. 7% with RSD 0. 6%,respectively. The result of multiplying a by β was less than 0. 5. The ratios of A261.5 a+b to βA242.5 a+b, and A242.5 a+b to αA261.5 a+b were both more than 1.2. According to new Vierordt method, the result is acceptable. Conclusion: The mothod is simple, rapid and repeat able. The interference of the two components on each other can be eliminated and the result is reliable.

关 键 词：联立方程新解法 醋酸泼尼松龙 马来酸氯苯那敏 

分 类 号：R927.2[医药卫生—药学]