E-钙粘素和γ-连环素与原发性肝癌侵袭转移的关系  

Expression of E-cadherin and γ-catenin in relation to invasion and metastasis in human hepatocellular carcinomas

作　　者：王辉[1] 韩亮[1] 李庆友[1] 

机构地区：[1]武汉市中心医院普外科,430014

出　　处：《腹部外科》2004年第6期370-372,共3页Journal of Abdominal Surgery

摘　　要：目的　探讨细胞粘附分子E 钙粘素 (E cadherin ,E cad)和γ 连环素 (γ catenin ,γ cat)与原发性肝癌侵袭转移的关系。方法　用SP免疫组化方法检测 34例人原发性肝细胞癌组织和 2 0例癌旁正常肝组织中E cad和γ cat的表达并进行半定量分析。结果　E cad和γ cat在正常肝组织中全部正常表达 ,而肝癌组织不同程度的表达减弱或缺失 ,两者的表达随肝癌的转移而有显著性的差异(P <0 .0 5 )。结论　检测E cad和γ cat的表达有助于判断肝癌的生长、浸润情况 ,可能为肿瘤侵袭、转移的早期干预提供新的依据。Objective Objective To study the correlation of E-cadherin and γ-catenin expression with invasion and metastasis in human hepatocellular carcinomas (HCC).Methods S-P immunohistochemical method was used to detect the E-cadherin and γ-catenin expression in 34 cases of HCC and 20 adjacent normal hepatic tissues by E-cadherin monoclonal antibody and γ-catenin polyclonal antibody.The results were densitometrically semiquantitated.Results All normal hepatic tissues expressed E-cadherin and γ-catenin normally,but the E-cadherin and γ-catenin expression were reduced or negative in HCC.The expression of E-cadherin and γ-catenin in HCC was associated with invasion and metastasis of HCC.Conclusion The expression of E-cadherin and γ-catenin are closely associated with invasion and metastasis of HCC,which suggests E-cadherin and γ-catenin may be new carcinomal markers.We can evaluate the invasion and metastasis of HCC by detecting the expression of E-cadherin and γ-catenin in HCC.

关 键 词：E-cad 表达 连环素 癌侵袭 原发性肝癌 E-钙粘素 转移 正常肝组织 免疫组化方法 人原发性肝细胞癌 

分 类 号：R735[医药卫生—肿瘤] R737[医药卫生—临床医学]