止吐药盐酸托烷司琼的合成  

Synthesis of antiemetic Tropisetron hydrochloride

作　　者：刘宇[1] 陆军[1] 陈宁[1] 苏国强[1] 

机构地区：[1]江苏省药物研究所,江苏南京210009

出　　处：《华西药学杂志》2004年第6期433-434,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　合成盐酸托烷司琼并改进其合成工艺。方法　以 3-吲哚甲酸为起始原料 ,经氯代、酯化、成盐酸反应制得长烷司琼。结果　所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论　此合成路线可行。OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process. METHODS Tropisetron hydrochloride was synthesized by steps of chlorination, esterification, and hydrochlorination.RESULTS Chemical structure of Tropisetron hydrochloride was confirmed by element analysis,UV,IR, 1HNMR, ESI-MS and EI etc. CONCLUSION This synthetic method is feasible.

关 键 词：成盐 盐酸托烷司琼 氯代 起始原料 合成路线 合成工艺 酯化 止吐药 反应 质谱 

分 类 号：R975.4[医药卫生—药品] TQ460.4[医药卫生—药学]