人血清瘦素和胰岛素样生长因子-Ⅰ水平与糖尿病视网膜病变的关系  

Correlation of serum leptin and insulin-like growth factor-I levels with diabetic retinopathy

作　　者：郑志[1] 李春霞[2] 潘红飚[1] 陈海冰[3] 

机构地区：[1]安徽省立医院眼科,合肥230001 [2]安徽省立医院内分泌科,合肥230001 [3]上海市中西医结合医院眼科

出　　处：《眼科研究》2004年第6期644-646,共3页Chinese Ophthalmic Research

摘　　要：目的 探讨瘦素和胰岛素样生长因子-I(IGF-I)在糖尿病视网膜病变(DR)发病机制中的作用。方法 对57例2型糖尿病患者(按照DR分级标准,再将其分为3个亚组)及50例健康对照者,采用放射免疫法进行血清瘦素和IGF-I浓度的检测。 结果 糖尿病患者血清瘦素水平(8.8±3.4)ng／mL与健康对照者(8.5±2.5)ng／mL比较,差异无显著性(P>0.05);增生型糖尿病视网膜病变(PDR)患者15例,血清瘦素水平(12.5±2.5)ng／mL显著性高于非PDR患者,19例,(9.4±1.2)ng/mL(P<0.01)及无DR患者23例,(6.2±1.6)ng／mL(P<0.01);非PDR患者血清瘦素水平也显著性高于无DR(P<0.01)。糖尿病患者血清IGF-I水平(188±38)ng／mL与健康对照者(136±42)ng/mL比较,差异有显著性(P<0.05)。PDR血清IGF-I水平(228±31)ng／mL显著性高于非PDR(186±55)ng／mL(P<0.01)及无DR(156±37)ng／mL(P<0.01);非PDR血清IGF-I水平也显著性高于无DR(P<0.01)。 结论 血清瘦索及IGF-I与DR及其严重程度显著相关,两者在DR发病机制中可能发挥重要作用,但两者之间并无相关性。Objective To investigate the effect of leptin and insulin-like growth factor-I (IGF-I) on pathogenesis of diabetic retinopathy (DR). Methods Fifty-seven patients with type 2 diabetes were assigned to different subgroups according to the DR degree, and 50 healthy volunteers served as controls. Fasting serum leptin and IGF-I were measured by radioimmunoassay. Results Serum leptin of the diabetic patients was insignificantly different from the control subjects (8. 8±3. 4 ng/mL vs 8. 5±2. 5 ng/mL,P >0. 05) and was significantly higher in proliferative diabetic retinopathy patients(PDR) (12. 5 ±2.5 ng/mL) than that without PDR patients(NPDR) (9. 4±1.2 ng/mL,P<0. 01) and no DR individuals(NoDR) (6.2±1.6 ng/mL,P <0. 01). Serum IGF-I of the diabetic patients was significantly different from the control subjucts(188±38 ng/mL vs 136±42ng/mL,P <0.05) and was significantly higher in PDR(228±31 ng/mL)than in NPDR(186±55 ng/mL,P < 0.01) and NoDR( 156±37 ng/mL,P<0. 01). Serum leptin and serum IGF-I levels in NPDR were also significantly higher than those in NoDR(P <0. 01 ) . Conclusion There is a significantly positive relation between leptin or IGF-I and the severity of DR. Leptin and IGF-I may play a role in the progression of human DR to a prolifirative phase. However, there is no positive correlation of leptin with IGF-I.

关 键 词：瘦素 胰岛素样生长因子-I 糖尿病视网膜病变 

分 类 号：R774.1[医药卫生—眼科]