肾癌细胞增殖活性与预后的关系  

The relationship between proliferating activity of renal carcinoma cells and prognosis

作　　者：陈至善[1] 熊显华[1] 

机构地区：[1]解放军第455医院,上海200052

出　　处：《临床肿瘤学杂志》1998年第2期7-8,共2页Chinese Clinical Oncology

摘　　要：目的:为了探索肾癌增殖细胞的生物学特性与预后的关系.方法:应用免疫组化ABC法和流式细胞术DNA分析技术.结果:检测42例肾癌PCNA阳性率(LI)平均为12.4±5.1%.其中二倍体18例,LI值为2.41±3.14%;异倍体24例,LI值为6.80±4.29%.以LI均值为界分组,A组LI值≤12.4%,有23例,5年生存率为60.9%(14/23);B组LI值>12.4%,有19例,5年生存率为15.8%(3/19).两组差异非常显著(P<0.01).结论:提示PCNA的LI值可作为判断恶性度的客观指标,DNA直方图可评估预后.Purpose: To investigate the relationship between proliferating activity of renal carcinoma cells and its progno-sis. Methods: Immunohistochemical method of ABC and flow cytometric analysis were used to examine proliferating cell nuclear antigens (PCNA) and DNA contents in forty-two samples of renal carcinoma. Results: PCNA positive rate (LI) was 12. 4?5.1% on average. LIs of DNA diploid (18/45) and aneuploid (24/45) were 2.14?.14% and 6. 8?. 29% respectively. LI of group A was less than or equal to 12. 4% while LI of group B was more than 12. 4%. Five-year survival rate was 15. 8% (3/ 19) in the former and 60. 9%(14/23) in the latter. The difference was significant statistically (P<0. 01). Conclusions:The re-sults suggest that LI of PCNA is a good indicator for accessing the degree of malignancy and DNA histogram may be used to pre-dict the prognosis.

关 键 词：预后 肾癌细胞 增殖活性 生存率 PCNA 免疫组化ABC法 恶性 流式细胞术 阳性率 异倍体 

分 类 号：R737.11[医药卫生—肿瘤] R735[医药卫生—临床医学]