负性生活事件在功能性消化不良发病中的作用  

The Role of Negative Life Events on the Onset of Functional Dyspepsia

作　　者：张志雄[1] 粱列新[1] 张法灿[1] 熊汉华[2] 

机构地区：[1]广西壮族自治区人民医院消化内科,南宁530021 [2]华中科技大学同济医学院附属协和医院消化内镜中心

出　　处：《临床消化病杂志》2004年第6期247-249,共3页Chinese Journal of Clinical Gastroenterology

基　　金：广西壮族自治区自然科学基金资助(基金编号 :桂科自 0 3390 2 9)

摘　　要：目的 :比较功能性消化不良 (FD)患者与健康人在负性生活事件、焦虑、抑郁等方面的差异 ,揭示负性生活事件与FD患者焦虑、抑郁的关系及其在FD发病中的作用。方法 :采用生活事件量表 (LES)、焦虑自评量表 (SAS)、抑郁自评量表 (SDS)对 1 30例FD患者及1 1 0例健康人进行评分。结果 :FD患者组负性生活事件分值显著高于健康人组 (2 8.65± 2 5 .2 3vs 1 5 .38± 1 8.77,P <0 .0 5) ,焦虑、抑郁分值也显著高于健康人组 (52 .65± 1 3 .2 9vs40 .85± 8.55 ;51 .34± 1 4 .67vs41 .67± 7.74,P <0 .0 0 1 )。FD患者负性生活事件分值与焦虑、抑郁分值呈正性相关 (r=0 .56、0 .52 ,P <0 .0 0 1 )。结论 :负性生活事件可能通过对个体心理健康的影响 ,进而影响功能性消化不良的发生。Objective:To compare the levels of negative life events,anxiety,depression between functional dyspepsial (FD) patients and healthy subjects.To explore the relationship between negative life events and anxiety and depression in FD patients.To reveal the role of negative events on the onset of FD.Methods:130 FD adult patients and 110 healthy subjects were enrolled into the study,negative life events of all subjects were assessed by revised life events scale (LES) and anxiety,depression were assessed by zung self-rating anxiety scale (SAS) and self-rating depression scale (SDS) respectively.Results:The score of LES was significanfiy higher in FD patients than that in healthy subjects (28.65±25.23 vs 15.38±18.77,P<0.05) and the scores of anxiety and depression were significantly higher in FD patients than those in healthy subjects (52.65±13.29 vs 40.85±8.55;51.34±14.67 vs 41.67±7.74,P<0.001).Life events was positively associated with anxiety and depression in FD patients. Conclusion:Negative life events may cause psychological morbidity in FD patients and induce the onset of functional dyspepsia.

关 键 词：功能性消化不良 负性生活事件 焦虑 抑郁 

分 类 号：R57[医药卫生—消化系统]