Polymorphism of Prodynorphin promoter is associated with schizophrenia in Chinese population  

作　　者：Chang-shunZHANG ZhengTAN LanYU Sheng-nanWU YingHE Niu-fanGU Guo-yinFENG LinHE 

机构地区：[1]Bio-XLifeScienceResearchCenter,ShanghaiJiaoTongUniversiity,Shanghai200030 [2]InstituteofNutritionScience,ChineseAcademyofSciences,Shanghai200031 [3]ShanghaiInstituteofMentalHeahh,Shanghai200030,China

出　　处：《Acta Pharmacologica Sinica》2004年第8期1022-1026,共5页中国药理学报（英文版）

摘　　要：AIM: To investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia. METHODS: SNPs in the promoter and exon regions of PDYN were screened and genotyped for association study in a cohort of Chinese Han schizophrenia cases and controls. RESULTS: Two SNPs PDYN-1576C>T and PDYN-946C>G were identified in the promoter region but PDYN-946C>G showed significant differences of allele distribution (x2=6.15, P=0.013) and genotype distribution (x2=6.87, P=0.032) between schizophrenic and control subjects. CONCLUSION: PDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia (P<0.05).AIM: To investigate the correlation between single nucleotide polymorphisms (SNPs) of functional candidate gene Prodynorphin (PDYN) and schizophrenia. METHODS: SNPs in the promoter and exon regions of PDYN were screened and genotyped for association study in a cohort of Chinese Han schizophrenia cases and controls. RESULTS: Two SNPs PDYN-1576C>T and PDYN-946C>G were identified in the promoter region but PDYN-946C>G showed significant differences of allele distribution (x2=6.15, P=0.013) and genotype distribution (x2=6.87, P=0.032) between schizophrenic and control subjects. CONCLUSION: PDYN-946C>G polymorphism demonstrated an association with population susceptibility to schizophrenia (P<0.05).

关 键 词：NEUROPEPTIDES PRODYNORPHIN single nucleotide polymorphism SCHIZOPHRENIA 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]