铅暴露引起的小鼠肝脏抗氧化系统损伤  

Antioxidant defense system damage in the liver of mouse exposed to lead

作　　者：徐进[1] 徐立红[1] 郑一凡[1] 邢鸣鸾[1] 唐建刚[1] 俞智勇[1] 

机构地区：[1]浙江大学医学院,杭州310031

出　　处：《环境科学学报》2004年第6期1142-1144,共3页Acta Scientiae Circumstantiae

基　　金：国家自然科学基金重点项目(20137010);国家自然科学基金面上项目(30270257)

摘　　要：小鼠暴露于不同浓度乙酸铅1周后,对肝脏还原性谷胱甘肽(GSH)、谷胱甘肽还原酶(GR)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、活性氧物质(ROS)、总氧自由基清除能力(TOSC)进行测定.结果显示:小鼠铅暴露后,肝脏GSH水平和TOSC值略有下降;GR、CAT、SOD活性被抑制,在高剂量铅暴露组尤为明显;ROS升高1 5倍.这些结果表明,铅能对小鼠肝脏的抗氧化系统造成损伤.GSH, GR, SOD, CAT, ROS, and TOSC in mouse liver were measured after exposure to lead acetate of different concentrations for one week. The results showed that GSH levels and TOSC decreased slightly, and the activity of GR, SOD and CAT were inhibited, especially in high lead concentration groups. While ROS levels increased 1.5-folds. These results indicate that lead can induce damage of antioxidant defense system in mouse liver.

关 键 词：铅暴露 小鼠 肝脏 鼠肝 GR 损伤 ROS 过氧化氢酶(CAT) 抗氧化系统 总氧自由基清除能力 

分 类 号：X171[环境科学与工程—环境科学] R977.9[医药卫生—药品]