螺旋藻(Spirulina)对慢性肝损伤小鼠肝组织抗氧化能力的影响  

Effect of Spirulina on Antioxdation Ability of Liver during CCl_4 Induced Chronic Liver Injury in Mice

作　　者：丁晶晶[1] 金安娜 施丽丽[3] 霍天瑶[3] 黄成[3] 

机构地区：[1]南京大学医学院 [2]江苏省职工医科大学 210029 [3]南京大学生命科学学院

出　　处：《湖泊科学》2004年第4期343-348,共6页Journal of Lake Sciences

基　　金：江苏省职工医科大学和南京大学合作科研项目资助.

摘　　要：用四氯化碳导致小鼠肝损伤,各组每日灌胃不同剂量螺旋藻,检测了饲养45d的小鼠血清的ALT活力、肝组织的SOD活力和MDA含量,分别建立ALT、SOD活力以及MDA含量随剂量(C)变化的函数,求出各项临界参数值,并对参数的生物学意义进行解释,以观察螺旋藻对肝损伤小鼠肝组织中SOD活力和MDA的影响.实验结果显示:螺旋藻能提高小鼠SOD的活力并降低其MDA含量,进一步验证了螺旋藻可提高肝损伤小鼠肝组织的抗氧化能力,分析结果还显示螺旋藻对肝组织抗氧化能力的提高既具有一定的量效累积性,也存在量效局限性.In this experiment. CCl4, was used to induce liver injury in mice. Different dosages of Spirulina are given in each group respectively for 45d. ALT activity in serum, SOD activity and MDA content in the mice's brain were assayed, the functions between the dosage of Spirulina ( C) and ALT, SOD, MDA values were formed with statistical methods. Relative critical values were calculated according to these functions and their biological meanings were explained. The results show that Spirulina can reduce ALT activity, improve SOD activity and reduce MDA content,and when the dosage of Spirulina overruns a certain value, the antioxidant ability of Spirulina is reduced. The specific parameters are as follows, the minimum effectual dosage to decrease ALT is 106. 4mg/kg; and that of MDA is 121. 3mg/kg, the maximum dosage to increase SOD is 385. 3mg/kg. It proves that Spirulina can enhance the antioxidant ability of liver in mice and alleviate liver injury caused by CCl4.

关 键 词：MDA含量 螺旋藻 SOD活力 饲养 肝组织 剂量 抗氧化能力 累积性 函数 实验结果 

分 类 号：R575[医药卫生—消化系统]