瘤苗特异性主动免疫治疗及其机制的实验研究  

Experimental Study on the Immunoprotective Effect and Mechanism of Action of Specific Active Immunization with Tumor Cell Vaccine

作　　者：钱振超[1] 王大庆[1] 金成钢[1] 乔健[1] 刘金友[1] 

机构地区：[1]大连医科大学肿瘤研究所,大连116003

出　　处：《中国肿瘤生物治疗杂志》1995年第2期120-126,共7页Chinese Journal of Cancer Biotherapy

基　　金："八五"国家医药科技攻关(No. 85-914-02-08)及国家自然科学基金(NO.38970356;39200048)等项目资助.有关痘苗病毒MH134;X5563瘤苗的研究工作在大阪大学微生物病研究所完成.

摘　　要：围绕中药莪术及其有效成分β-榄香烯的抗癌作用与原理的研究,用多种小鼠可移植性瘤株,比较系统、深入地研究了中药(莪术油、β-揽香烯等)、化学药品(MMC、戊二醛等)、放射能(^(60)Co、X线等)及/或病毒(痘苗病毒、新城鸡瘟病毒)等处理的肿瘤细胞疫苗或其膜组分(Mfr)的主动免疫防治效应及其规律和机制,获得了明显的可重复的阳性结果,解决了有关瘤苗制备、保存和使用方法等一系列问题.Through several murine transplantable tumor models, we studied the immunoprotective effect and mechanism of action of specific active immunization with various tumor cell vaccines (TCV) treated by: (1) Oleum Curcuma Aromatica (OCA, a Chinese anticancer medicament) and its effective monomer β-elemene; (2) MMC and glutaraldehyde; (3) ^(60)Co and X-ray irradiation; and (4) vaccinia virus (VV) and newcastle disease virus (NDV), including virus infected TCV membrane fraction (Mfr). The reproducible results of immunoprotective effect indicated that the specific active immunotherapy with such TCVs might be of practical value in clinical immunological approaches to cancer therapeutics.

关 键 词：瘤苗 特异性主动免疫治疗 中药 实验研究 莪术油 Β-榄香烯 新城鸡瘟病毒 组分 制备 戊二醛 

分 类 号：R730[医药卫生—肿瘤] R735[医药卫生—临床医学]