卵巢癌细胞C-erbB_(2)表达与LAK杀伤活性的关系及IFN-γ的体外调控影响  

Relationship Between C-erbB_(2) Expression and Lysis Activity of Lymphokine-Activated Killer Cells in Ovarian Cancer and in vitro Regulation by γ-Interferon

作　　者：金志军[1] 吴直江[2] 费俭[2] 张惜阴[3] 丰有吉[3] 吕彪[4] 

机构地区：[1]第二军医大学长征医院妇产科,上海200003 [2]中国科学院上海细胞生物学研究所 [3]上海医科大学妇产科医院 [4]上海医科大学基础医学院病理生理学教研室

出　　处：《中国肿瘤生物治疗杂志》1995年第3期185-187,共3页Chinese Journal of Cancer Biotherapy

基　　金：国家教委博士点基金资助

摘　　要：利用卵巢癌细胞株进行C-erbB_2表达与LAK杀伤活性的关系及IFN-γ的调控研究。结果表明3AO细胞C-erbB_2扩增和高表达;AO细胞C-erbB_2正常拷贝和低表达;LAK对AO细胞的杀伤活性为36.0±28.9,明显大于对3AO细胞的杀伤活性(27.6±18.7);IFN-γ可降低3AO细胞C-erbB_2的表达,提高LAK对3AO细胞的杀伤活性,但对AO细胞无显著影响。提示:卵巢癌细胞C-erbB_2的过表达可抑制LAK的杀伤活性;IFN-γ可降低C-erbB_2的过表达,从而改善LAK的杀伤活性。Using ovarian cancer cell lines, we studied relationship between C-erbB2 expression and lysis activity of lymphokine-activated killer cells (LAK) and in vitro regulation by γ-interferon (IFN-γ). The results showed that C-erbB2 overexpression was associated with resistance to lysis activity of LAK in ovarian cancer; IFN-γ could reduce the overexpression of C-erbB2 and increase lysis activity of LAK on ovarian cancer cells in which C-erbB2 were overexpressed.

关 键 词：卵巢癌 癌基因 淋巴因子激活杀伤细胞 Γ-干扰素 

分 类 号：R737.31[医药卫生—肿瘤] R735[医药卫生—临床医学]