青心酮对人血管内皮细胞tPA和PAI生成的影响  

The regulatory effect of 3, 4 - Dihydroxyacetophenone on tPA and PAI activity of the vascular endothelial calls

作　　者：闪珍珍[1,2] 常翠芳[1,2] 吴熙瑞[1,2] 冯玲[1,2] 

机构地区：[1]同济医科大学计划生育研究所 [2]同济医院

出　　处：《中药药理与临床》1995年第6期33-35,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：以发色底物分解产色法检测了青心酮对培养的人脐静脉内皮细胞ｔＰＡ和ＰＡＩ活性的影响。结果显示青心酮具有调节ＰＡＩ和ｔＰＡ平衡的作用，由于对ＰＡＩ的抑制作用明显强于对ｔＰＡ的作用，ＰＡＩ／ｔＰＡ比值明显下降，此调节作用并呈现一定的量效关系。因此，ＤＨＡＰ改善器官如子宫胎盘的微循环可能与其调节血管内皮细胞ＰＡＩ／ｔＰＡ活性平衡的作用有关。he effect of DHAP on PAI and tPA activity of cultured humanumbilical vein endothelial cells has been investigated by special substrata decomposition method. The result demonstrated that DHAP play a role in resulating the balance of PAl and tPA activity. As the inhibitory effect of DHAP on PAl was stronger than that on tPA, the PAI/tPAshowed declining. Furthermore, the inhibitory effect was related to the dosage. Therefore, it was considered that improvement of uteroplacental microcirculation by DHAP might be related to its regulating effect on balance of PAI/tPAof vascular endothelial cells.

关 键 词：青心酮 人血管内皮细胞 TPA PAI 药理作用 组织型纤溶酶原激活物 纤溶酶原激活物抑制物 冬青叶 

分 类 号：R285[医药卫生—中药学]