奥硝唑乳膏的制备及质量控制  

Preparation and Quality Control of Ornidazole Cream

作　　者：杨征[1] 陈雅[1] 吴畏[1] 舒凌玲[1] 

机构地区：[1]第三军医大学野战外科研究所大坪医院药学部,重庆400042

出　　处：《中国药业》2004年第12期48-49,共2页China Pharmaceuticals

摘　　要：目的:制备奥硝唑乳膏并对其进行含量测定。方法:将奥硝唑制成5%的乳膏,采用紫外分光光度法对其进行质量控制。结果:奥硝唑线性范围为8.08～40.40μg/mL,回归方程为C=24.9187A-0.4021,r=0.9999(n=5),平均回收率为99.13%,RSD=0.37%(n=5)。结论:该制剂制备方法操作简便,质控容易,适合于医院制剂。Objective:To prepare ornidazole cream and to determine the content of ornidazole.Methods:To prepare 5%ornidazole cream and take quality control by UV spectrophotometery.Results:A good linearity for ornidazole was observed in the range of 8.08～40.40 μg/mL. The regression equation was C=24.918 7A-0.402 1,r=0.999 9(n=5).The average recovery was 99.13%,RSD=0.37%(n=5). Conclusion:The method is simple and easy for operation and quality control in hospital preparation.

关 键 词：奥硝唑乳膏 制备 质量控制 

分 类 号：R944.2[医药卫生—药剂学] R978.61[医药卫生—药学]