立体定向多靶点联合射频毁损术治疗难治性精神病  

Stereotactic multiple target radiofrequency lesion for treatment of intractable psychosis

作　　者：宋剑[1] 郭常利[1] 宋敏花[1] 周剑云[1] 王争[1] 刘建峰[1] 

机构地区：[1]河北医科大学第一医院神经外科,石家庄050031

出　　处：《立体定向和功能性神经外科杂志》2004年第6期329-331,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

基　　金：河北医科大学第一医院青年科技基金项目 (编号 :2 0 0 3 0 0 1)

摘　　要：目的　探讨脑立体定向多靶点联合射频毁损手术在治疗难治性精神病中的作用。方法　对 10例难治性精神病患者应用立体定向技术对颅内杏仁核、内囊前肢、扣带回等部位进行多靶点组合射频热凝治疗。应用简明精神病评定量表 (briefpsychiatricratingscale,BPRS)、社会功能量表 (socialdisabilityscreeningschedule,SDSS)、韦氏智力量和临床记忆量表对治疗效果进行评定 ,并随访病人 6个月～ 1年。结果　 10例患者中治愈 2例 ,显著进步 3例 ,进步 2例 ,无变化 3例。手术前后BPRS、SDSS量表检查有显著差异 ,临床记忆量表测验、韦氏智力测验病人脑功能变化与术前无显著差异。结论　立体定向多靶点联合射频毁损手术是治疗难治性精神病的有效治疗方法 ,根据不同症状设计不同靶点组合做到手术计划个体化 ,对提高疗效、降低并发症有较大意义。Objective To investigate the effect of stereotactic multiple target radiofrequency lesion for treatment of intractable psychosis.Methods 10 cases of intractable psychosis were treated by stereotactic technique with bilateral multiple nuclei lesion by radiofrequency thermocoagulation including amygdatotomy,capsulotomy and subcaudate tractotomy.The therapeutic effects were estimated with BPRS,SDSS and WISC.Results 2 patients were cared,3 patients were respectively improved,2 patients were improved and 3 patients were no improvement with follow-up 6～12 months after operation.There is significance different in BPRS and SDSS between preoperative and postoperative.Conclusion The stereotactic multiple target radiofrequency surgery is an effective method for treatment of intractable psychosis.

关 键 词：立体定向手术 难治性精神病 多靶点 射频 

分 类 号：R749.05[医药卫生—神经病学与精神病学]