抗轮状病毒免疫球蛋白对轮状病毒肠炎疗效的研究  

Effect of anti-RV immunoglobulin therapy on infants with rotavirus enteritis

作　　者：金玉[1] 董巧丽[1] 李宇宁[1] 薛君莉[1] 余唯琪[1] 李玉梅[1] 林丽星[1] 王育哲[1] 

机构地区：[1]兰州医学院第一附属医院儿科,甘肃兰州730000

出　　处：《小儿急救医学》2004年第6期366-368,共3页Pediatric Emergency Medicine

基　　金：甘肃省教育厅科研基金资助项目 ( 9672 0 )

摘　　要：目的　观察抗轮状病毒免疫球蛋白 (Anti RVIgY即Igr或IgG)治疗轮状病毒肠炎的疗效。方法　应用ELISA方法诊断急性轮状病毒肠炎 2 14例 ,随机分为A组 (72例 )、B组 (5 6例 )及C组(86例 ) ,分别给予口服Anti RVIgY、Anti RVIgY +思密达、常规药物 (思密达 )治疗。 结果　A组及B组 3d总治愈率分别为 37 5 %、4 1 1% ,与C组 (16 3% )比较 ,有显著性差异 (P <0 0 1) ,A组及B组总有效率分别为 77 8%、80 4 % ,两组疗效比较无显著性差异 ,但与C组 (5 0 0 % )比较 ,有显著性差异 (P<0 0 1)。结论　 (1)Anti RVIgY治疗轮状病毒肠炎效果显著 ,服用方便 ,治疗中未发现毒副反应 ;(2 )思密达与Anti RVIgY合用 ,对其疗效无明显影响 。Objective To evaluate effect and safety of oral anti-RV immunoglobulin of hens egg yolk IgY therapy on infants with rotavirus enteritis.Methods 214 infants with rotavirus enteritis were randomly divided into three groups.72 infants were received Anti-RV (IgY)in the treatment group.56 infants were received Anti-RV IgY and Smecta in the objective group.86 infants were received routine medicine in the control group.All the patients were received the same supporting therapy.Oral rehydration solution and/or venous infusion were used to correct water electrolyte balance if there was dehydration.Results The total effective rate in the group A was 77.8% and significantly higher than the group C (50.0% P<0.01).The total effective rate in the group B was 80.4%,compared with the group A no significant differences (P>0.05).Conclusion Anti-RV (IgY) is effective,safe and convenient for infantile rotavirus enteritis.Combined with Smecta was effective for treating infants with rotavirus enteritis and should be recommended anti-RV-IgG.

关 键 词：轮状病毒肠炎 抗轮状病毒免疫球蛋白 治疗 疗效 

分 类 号：R725.1[医药卫生—儿科]