灯盏乙素对实验性大鼠局灶脑缺血的保护作用  

Beneficial effects of scutellarin injection on experimental focal cerebral ischemia in rats

作　　者：阮志鹏[1] 韩冬[1] 于卫东[1] 原梅[1] 李敬来[1] 

机构地区：[1]福建省莆田学院药学系,福建莆田351100

出　　处：《遵义医学院学报》2004年第5期453-455,共3页Journal of Zunyi Medical University

基　　金：校科研基金资助。

摘　　要：目的　采用大脑中动脉阻塞 (MACO)诱导大鼠局灶性脑缺血模型的方法 ,探讨灯盏乙素对大鼠大脑中动脉闭塞所致局部脑缺血的防治作用。方法　应用生理盐水作为对照组 ,以神经行为学评分、脑梗塞体积、脑含水测定作为指标。结果　灯盏乙素 4 0、80mg·kg-1静脉注射可显著缩小梗塞体积 ,改善行为障碍 ,显著降低脑含水量。结论　灯盏乙素对局灶性脑缺血具有保护作用。Objective To study the protective effects of scutellarin on rat focal cerebral ischemic injury by middle cerebral artery occlusion. Methods The neurological deficits.and infarct volume and water content were observed to evaluate effects of focal cerebral ischemia and salt was set as control. Results Treatment with scutellarin 20 or 40 mg·kg -1 iv was show to significantly reduce the cerebral infarct volume and water content, attenuate neurological deficits. Conclusions These results indicate that Scutellarin protects rats from ischemic neurological damage.[

关 键 词：灯盏乙素 脑局部缺血 梗死体积 行为评分 

分 类 号：R743.31[医药卫生—神经病学与精神病学]