阿立哌唑的合成  

Synthesis of Aripiprazole

作　　者：王军玲[1] 贾湘曼[1] 鲍春和[1] 陈子明[1] 蒋晔[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017

出　　处：《中国医药工业杂志》2004年第12期707-708,共2页Chinese Journal of Pharmaceuticals

摘　　要：间氨基酚和3-氯丙酰氯制得的酰胺在无水三氯化铝作用下环合得7-羟基-3,4-二氢-2(1H)-喹诺酮,与1,4-二溴丁烷成醚后与1-(2,3-二氯苯基)哌嗪进行取代反应制得抗精神病药阿立哌唑,总收率25%。Aripiprazole was synthesized from 3-aminophenol and 3-chloropropionylchlorideby condensation and cyclization in presence of AlCl3 to give 7-hydroxy-3,4-dihydro-2(1H)-quinolinone, which subjected to etherification with 1,4-dibromobutane and then condensation with 1-(2,3-dichlorophenyl)piperazine in an overallyield of 25%.

关 键 词：阿立哌唑 抗精神病药 合成 

分 类 号：R971.41[医药卫生—药品]