含氟、硝基苯并咪唑衍生物的合成及抗病毒活性  

Synthesis and Antiviral Activity of Fluorine-Containing Nitro Benzimidazole Derivatives

作　　者：陈洪[1] 黄思庆[1] 符史良[1] 欧春艳[1] 谢建英[1] 刘德海[1] 

机构地区：[1]湛江海洋大学,广东湛江524088

出　　处：《农药》2004年第12期549-551,共3页Agrochemicals

摘　　要：在碱性条件下由2-(4′-羟苯基)-5-取代苯并咪唑与氯乙酸作用得到5个新化合物取代苯并咪唑基苯氧乙酸。使其在4-二甲氨基吡啶催化下与溴代乙酰糖酯化合成了3个新化合物-含氟、硝基苯并咪唑苯氧乙酸糖酯。经IR、MS、1HNMR确认了这8个新化合物的结构及酯类化合物的构型。试验结果表明,含氟、硝基苯并咪唑苯氧乙酸糖酯较取代苯并咪唑基苯氧乙酸具有更高的抗烟草花叶病毒(TMV)的活性。Five new 4-(substituted benzimidazole-2-yl) phenoxyacetic acid compounds were synthesized by reacting2-(4′-hydroxyphenyl)-5-substituted benzimidazoles with chloroacetic acid under basic conditions. Three new fluo-rine-containing nitro benzimidazole derivatives were synthesized in the presence of 4-dimethylaminepyridine andtheir structure and configuration were confirmed by elemental analysis, IR, and 1HNMR. The new fluorine-containing,nitro benzimidazole derivatives have better antiviral activity against tobacco mosaic virus than 4-(substituted benzimi-dazole-2-yl) phenoxyacetic acid.

关 键 词：苯并咪唑 4-二甲氨基吡啶 苯氧乙酸糖酯 抗病毒活性 

分 类 号：TQ450[化学工程—农药化工]