乳腺癌组织胰岛素样生长因子I型受体的表达与病理学变化及预后的关系  

Relationship of the expression of insulin-like growth factor-I receptor with the pathological changes and prognosis of breast cancer

作　　者：季晨阳[1] 刘来昱[2] 罗荣城[1] 李爱民[1] 

机构地区：[1]解放军第一军医大学南方医院肿瘤科,广东省广州市510515 [2]解放军第一军医大学南方医院呼吸科,广东省广州市510515

出　　处：《中国临床康复》2004年第35期8003-8005,共3页Chinese Journal of Clinical Rehabilitation

基　　金：广东省医学科学技术研究基金(A1999339);解放军第一军医大学南方医院院长基金~~

摘　　要：目的:研究乳腺癌胰岛素样生长因子I型受体(insulin-likegrowthfactor-Ireceptor,IGF-IR)的表达与乳腺癌各种病理学指标之间的相关性,从而评价乳腺癌IGF-IR表达与乳腺癌预后的关系。方法:收集120例乳腺癌组织、29例乳腺癌淋巴结转移癌组织病理石蜡块,用免疫组织化学的方法测定IGF-IR的表达,将表达程度分为0,1,2,3级,2和3级定义为高表达。回顾性研究120例乳腺癌病例的肿瘤大小、淋巴结转移、病理学类型、间质反应、肿瘤分化。将IGF-IR的表达与各项病理指标比较,运用统计学方法进行分析。结果:①IGF-IR在乳腺癌原发灶癌组织中的高表达高于淋巴结转移癌组织(χ2=5.042,P=0.025)。②低分化乳腺癌IGF-IR高表达比高分化乳腺癌IGF-IR高表达明显减少(χ2=8.955,P=0.003)。③IGF-IR的表达与患者的肿瘤大小、淋巴结转移、临床分期、病理类型、间质反应无相关性。结论:IGF-IR可能在乳腺癌抗转移方面扮演了一定的角色,IGF-IR的高表达可能与乳腺癌分化状态相关,提示较好的预后。AIM:To study the correlation between the expression of insulin-like growth factor I receptor(IGF-IR) and pathological parameters in human breast cancer specimens so as to evaluate the relationship between IGF-IR expression and breast cancer prognosis. METHODS:The expression of IGF-IR was evaluated in 120 breast cancer specimens and 29 paraffin blocks of lymph nodes metastasis specimens using immmunohistochemistry.The expression was rated on four scales:grade 0,1,2 and 3,of which grades 2 and 3 were defined as high-expression.The tumor size,lymph node involvement,pathological type,stromal reaction,tumor differentiation of the 120 breast cancer specimens were reviewed.IGF-IR expression in breast cancer was compared with pathology parameters,and analyzed with statistical methods. RESULTS:①The high expression of IGF-IR in primary lesion was higher than that in the 29 lymph nodes metastasis specimens(χ2 =5.042,P =0.025).The high expression of IGF-IR in low differentiation specimens was lower than that in the high differentiation specimens(χ2=8.955,P=0.003).③No significant correlation was observed between expression of IGF-IR and tumor size,lymph node involvement,pathological type,stromal reaction. CONCLUSION:IGF-IR may play a certain role in anti-metastasis of breast cancer.The high expression of IGF-IR may be correlated with the differentiation of breast cancer,which indicates a good prognosis.

关 键 词：乳腺肿瘤 受体 胰岛素样生长因子Ⅰ 细胞分化 

分 类 号：R73[医药卫生—肿瘤]