ACE基因多态性与脑梗死、脑出血发病的关系  

Analysis of relation between angiotensin coverting enzyme (ACE) gene polymorphism and cerebral infarct, cerebral hemorrhage

作　　者：潘倩莹[1] 孙筱放[1] 廖宝平[1] 李少英[1] 孔舒[1] 

机构地区：[1]广州医学院附属广州市第二人民医院妇产科研究室,广东广州510150

出　　处：《中国现代医学杂志》2004年第23期50-52,共3页China Journal of Modern Medicine

摘　　要：目的探讨血管紧张素转换酶(ACE)基因多态性(I/D)与脑梗死、脑出血发病的关系。方法采用聚合酶链反应(PCR)技术,对323例脑梗死患者、340例脑出血患者和55例正常人进行血管紧张素转换酶基因型检测。结果脑梗死组DD,ID和II基因型频率分别为20.7%,37.8%和41.5%,与正常对照组比较差异无显著性(χ2=1.918,1.781,0.043和P >0.05),脑出血组DD,ID和II基因型频率分别为21.8%,41.4%和36.5%,与正常对照组比较差异无显著性(χ2=2.506,0.653和0.253,P >0.05)。脑梗死组D和I等位基因型频率分别为39.6%和60.4%,与正常对照组比较差异无显著性(χ2=0.421和0.421,P >0.05),脑出血组D和I等位基因型频率分别为42.5%和57.5%,与正常对照组比较差异无显著性(χ2=1.608和1.608,P >0.05)。结论血管紧张素转换酶基因多态性与脑梗死、脑出血的发病无相关。Objective: To study the correlation between angiotensin coverting enzyme (ACE) gene polymorphism and cerebral infarct,cerebral hemorrhage. Methods: With polymerase chain reation (PCR), we detected ACE geno-types in 323 patients with cerebral infarct, 340 patients with cerebral hemorrhage and 55 health persons. Results: The frequency of DD, ID and II genotype among cerebral infarct patients were 20.7%, 37.8% and 41.5% respectively. There were no significant difference between cerebral infarct patients and health persons (χ2=1.918, 1.781, 0.043, P >0.05). The frequency of DD, ID and II genotype among cerebral hemorrhage patients was respectively 21.8%, 41.5%, 36.5%. There were no significant difference between cerebral hemorrhage patients and health persons (χ2=2.506, 0.653, 0.253, P >0.05). The frequency of D and I allele gene among cerebral infarct patients was respectively 39.6%, 60.4%. There were no significant difference between cerebral infarct patients and health persons (χ2=0.421, 0.421, P >0.05). The frequency of D and I allele among cerebral hemorrhage patients was respectively 42.5%,57.5%. There were no significant difference between cerebral hemorrhage patients and healthpersons (χ2=1.608, 1.608, P >0.05). Conclusion: There is no correlation between ACE gene polymorphism and cerebral infarct, cerebral hemorrhage.

关 键 词：血管紧张素转换酶 基因多态 脑梗死 脑出血 

分 类 号：R743[医药卫生—神经病学与精神病学]