木犀草素缩苯胺席夫碱配合物的合成及抑菌活性  

Syntheses and antibacterial activity of metal-complexes of luteolin schiff base

作　　者：沙靖全[1] 李敬芬[2] 闫红[1] 

机构地区：[1]佳木斯大学化学与药学院,黑龙江佳木斯154007 [2]浙江湖州师范学院,浙江湖州313000

出　　处：《黑龙江医药科学》2004年第6期11-12,共2页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省教育厅资助项目

摘　　要：目的 :基于木犀草素的生物活性和席夫碱的特有性质基础上 ,设计与金属形成一系列新型席夫碱金属配合物。方法 :利用缩合反应 ,在无水乙醇中合成未见报道的黄酮类席夫碱过渡金属配合物。并通过元素分析、紫外光谱、红外光谱、摩尔电导等手段对其进行了结构表征和抗菌活性实验。结果 :通过分析 ,初步确定了其分子式、结构和其生物活性。结论 :结构式为 :配合物 MLx.n C2 H5OH。Objective: To design and synthesize a new type of schiff base and its complexes on the basis of luteolin bioactivity and schiff base traits. Method: A series of metal-complexes were synthesized by using condensation reaction. These compounds were characterized by elemental analysis, ultraviolet spectra, infrared spectra, molar conductance, and their antibacterial activity experiment was done. Result: Their ingredients and molecular structural formula and antibacterial activity were determined. Conclusion: The structure formula is ML x.nC 2H 5OH which has a high antibacterial activity.

关 键 词：席夫碱 金属配合物 抗菌活性 

分 类 号：R914.5[医药卫生—药物化学]