Comparison of Soleus Muscle Fibers in Rats and Rabbits at Different Stages of Postnatal Development  

大鼠和家兔生后发育各阶段比目鱼肌纤维的比较(英文)

作　　者：朱道立[1] 王康乐[1] 陈佩林[1] 

机构地区：[1]南通大学生命科学与技术系,江苏南通226007

出　　处：《Zoological Research》2004年第6期543-550,共8页动物学研究（英文）

基　　金：江苏省教育厅资助项目~~

摘　　要：In the present study,the effects of postnatal development on the number and distribution of skeletal muscle fibers of different types in hind leg of rat and rabbit were studied.The soleus muscles of rats aged 2 days,2,4,6,8,and 10 weeks (body weight 10,32,95,190,280,and 320 g),and rabbits aged 2 days,2,4,8,12,16,20,and 24 weeks (body weight 100,220,400,750,1 200,1 600,2 100,and 2 500 g) were stained with succinic dehydrogenase.With an image analysis system,the X-Y coordinates of fibers were used to analyze the growth-related changes.The results of present study showed that three types of fibers were found in the soleus muscles of rat and rabbit,i.e.,type Ⅰ (slow oxidative),ⅡX (fast oxidative),and ⅡA (fast oxidative glycolytic).The type Ⅰ fibers were present throughout the muscle that had a uniform distribution and tended to increase in number with aging.Type ⅡX fibers were scattered throughout the muscle and decreased markedly in number with aging.Type ⅡA fibers were located at the central and deep regions,and showed a little or no change in number and distribution with aging.While be of age,type ⅡA and ⅡX fibers became restricted to the superficial region.No type ⅡB fibers were detected.Type ⅡA fibers had the largest diameter,type Ⅰ intermediate and type ⅡX the smallest.Mean cross-sectional area of each type fibers of rabbits was larger than that of rats.The present results indicate that the number and distribution of muscle fibers of different types in hind limb of rat and rabbit change with the process of postnatal growth.为研究大鼠与家兔骨骼肌各类型肌纤维的数量和二维分布以及生后发育对其影响 ,取生后 2d和 2、4、 6、 8、 10周龄 (体重 10g和 32、 95、 190、 2 80、 32 0g)大鼠及生后 2d和 2、 4、 8、 12、 16、 2 0、 2 4周龄(体重 10 0g和 2 2 0、 4 0 0、 75 0、 12 0 0、 16 0 0、 2 10 0、 2 5 0 0g)家兔的比目鱼肌做琥珀酸脱氢酶染色。实验结果表明 ,大鼠和家兔比目鱼肌纤维被分成Ⅰ型 (SO) ,ⅡX型 (FO)和ⅡA型 (FOG) 3型。使用图像分析系统分析每型肌纤维在生后发育各阶段的相关变化 ,大鼠和家兔比目鱼肌中 :Ⅰ型纤维分布于整块肌肉 ,其数量随着生后发育而增加。幼体ⅡX型纤维分布在整块肌肉中 ,其数量随生后发育而减少 ;ⅡA型分布在肌肉中深层 ,数量几乎无变化 ;至成体时只有少量的ⅡX和ⅡA分布在肌表层。整个发育期间未见ⅡB型纤维。ⅡA型纤维直径最大 ,Ⅰ型中等 ,而ⅡX型最小。家兔 3型肌纤维的平均横切面积比大鼠的大。这些结果表明大鼠和家兔后肢肌各种类型肌纤维的数量比例和分布随生长过程发生改变。

关 键 词：RAT RABBIT Muscle fiber type Postnatal development 

分 类 号：Q954.66[生物学—动物学]