云绿茶对染铅小鼠驱铅效果实验观察  

The Effect of Yunnan Green Tea on the Excretion of Lead in Mice

作　　者：曾建明[1] 郭亚东[2] 侯景龙[1] 袁聪玲[1] 

机构地区：[1]昆明医学院营养与食品研究所,昆明650031 [2]昆明医学院实验中心,昆明650031

出　　处：《昆明医学院学报》2004年第4期14-16,共3页Journal of Kunming Medical College

摘　　要：目的 :观察了解云南绿茶对染铅小鼠的驱铅作用并比较云南绿茶与二巯基丁二酸 (DMSA)的驱铅效果 .方法 :将 4 8只小鼠分为阴性不染铅对照组和染铅组 (以 5 0 g/L醋酸铅溶液作为小鼠饮水染铅6 5d) .随后将染铅造模后的小鼠再随机分为 3个组 ,用云绿茶和DMSA分别处理其中两个组 ,剩下一组为不驱铅阳性对照 ,处理时间为 2 8d .处死动物 ,取小鼠双侧股骨测其骨铅含量 ,做组间骨铅含量比较 .结果 :不同处理的四个组动物骨铅含量差异存在极显著性 (P <0 0 1) .以阳性对照骨铅含量为 1作比较 ,驱铅效力 :DMSA为 0 34,云绿茶为 0 2 1.云绿茶促排铅作用不及DMSA ,但云绿茶有一定驱铅功效 .Objective: Compared with the Dimercaptosuccinic Acid (DMSA),we studied the effect of Yunnan Green Tea(YGT) on the excretion of lead in lead-exposed mice. Methods: 48 mice were divided into 2 groups. One was non-exposure normal control group, 12 mice and the other 36 mice were exposed to 5.0g/L solution of lead acetate by drinking for 65 days, and then divided the 36 Pb-exposed mice into 3 groups (12 mice per group),one of them was positive control, which was not given any specific detoxification. The other two groups were perfused orally with different liquid. One was perfused with DMSA and the other with YGT for 28 days. After 4 weeks of administration, the contents of lead in thighbone of all mice were examined. Results: It was found that the contents of lead in thighbone were significantly different (P<0.01) among the control and differently treated groups. The content of lead in the positive control was the highest and in the same proportion it was regarded as a hundred percent, the lead content in the DMSA group decreased 34%,the lead content of the YGT group decreased 21%,which indicated that YGT could accelerate the excretion of lead in thighbone of mice.

关 键 词：染铅 小鼠 驱铅 DMSA 绿茶 实验观察 铅含量 动物骨 排铅作用 功效 

分 类 号：R595.2[医药卫生—内科学] R135.11[医药卫生—临床医学]