髓系/自然杀伤细胞祖细胞急性白血病(附1例报道并文献复习)  

MYELOID/NATURAL KILLER CELL PRECURSOR ACUTE LEUKEMIA(ONE CASE REPORT AND LITERATURE REVIEW)

作　　者：张莉[1] 王世宏[1] 李睿[1] 宫本法[1] 王慧君[1] 郝玉书[1] 肖志坚[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院血液内科,天津300020

出　　处：《白血病．淋巴瘤》2004年第6期326-329,共4页Journal of Leukemia & Lymphoma

摘　　要：目的:提高对髓系/自然杀伤细胞祖细胞(myeloid/natural killer cell precursor,M/NKP )急性白血病的认识。方法:报告1例M/NKP急性白血病并复习相关文献。结果:M/NKP急性白血病起源于髓系和NK细胞共同的祖细胞。白血病细胞形态学特征类似急性淋巴细胞白血病L2型,胞体大小不等,核圆或不规则,核仁明显,胞质苍白,无嗜天青颗粒,髓过氧化物酶(MPO)染色阴性,免疫表型特征为表达CD7,CD33,CD34,CD56和HLA-DR,其他NK细胞及T、B细胞分化抗原阴性。临床特征为髓外浸润较常见,急性髓系白血病化疗方案疗效相对较好,但预后差。结论:M/NKP急性白血病具有独特的临床和实验室特征,是有别于其他NK细胞及髓系细胞恶性疾病的一类独立疾病。Objective: To improve the recognization of myeloid/natural killer(NK) cell precursor acute leukemia. Methods: A case of myeloid/NK cell precursor acute leukemia was reported and the related literature was reviewed. Results: Myeloid/NK cell precursor acute leukemia which might origin from common progenitor between the NK cell and myeloid lineage. Morphologly, the leukemic cells generally showed acute lymphoblatic leukemia L2- shaped,with variation in cell size, round to irregular nuclei and prominent nucleioli, pale cytoplasm, and a lack of azurophilic granules. Cytochemical myeloperoxidase staining showed negative reactivity.The leukemic cells phenotype were characterized by co- expression of CD7,CD33,CD34,CD56 and frequently HLA- DR,but without expression of other NK, T cell, and B- cell markers. Clinically,the patients were characterized by remarkable extramedullary involvement, myeloid chemosensitivity and poor prognosis. Conclusion: Myeloid/NK cell precursor acute leukemia is a distinct biologic and clinical entity, which is distinguishable from other NK cell and myeloid malignancies.

关 键 词：白血病 急性 髓系/自然杀伤细胞祖细胞CD56 急性髓系白血病M0 

分 类 号：R733.72[医药卫生—肿瘤]