酵母与新药研究  

Yeast for New Drug Research

作　　者：胡亚楠[1] 刘睿[1] 吴梧桐[1] 叶波平[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009

出　　处：《中国药科大学学报》2004年第6期590-594,共5页Journal of China Pharmaceutical University

基　　金：霍英东教育基金会第九届高等院校青年教师基金项目(No.91039);江苏省自然科学基金创新人才项目(No.BK2002418)~~

摘　　要：酵母中约有31%的编码基因与哺乳动物的一些重要功能基因具有很高的同源性,这为人类对生命现象的认识带来了新的思考,并将推动药物作用靶点、药物的毒副作用的研究。文章围绕酵母这种“模式”生物建立的几种技术平台的发展和特点,简要综述了它们在药物研究领域中的应用。As a kind of eukaryotic cell,yeast has been one of model organisms widely used in biology and bio-medicine area for more than one century.The first complete DNA sequence of a eukaryotic genome from Saccharomyces cerevisiae was released in 1996 and it made us know more about its genetic background.The phenomenon of these genes in yeast and mammals that encode very similar proteins gave us the chance of understanding primary drug action,drug side effect and chemical toxicity.The characteristics of techniques about yeast and their applications used in new drug research were discussed.

关 键 词：酵母 同源基因 表面展示 双杂交系统 新药研究 

分 类 号：R91[医药卫生—药学]