复方奥硝唑含漱液的制备及质量控制  

Preparation and Quality Control of Compound Ornidazole Gargle

作　　者：陈雅[1] 杨征[1] 吴畏[1] 舒凌玲[1] 党莉[1] 

机构地区：[1]第三军医大学野战外科研究所大坪医院药学部,重庆400042

出　　处：《中国药师》2005年第1期36-37,共2页China Pharmacist

摘　　要：目的:制备复方奥硝唑含漱液并建立其含量测定方法。方法:将奥哨唑和醋酸氯已定制成含漱剂,采用双波长分光光度法在317nm波长处测定奥硝唑含量,在247nm和278nm波长处测定醋酸氯已定含量。结果:奥硝唑的平均回收率为99.66％,RSD=0.40％(n=5);醋酸氯已定的平均回收率为100.21％,RSD=0.84％(n=5)。结论:该制剂制备方法简便易行,质量可控,适于医院使用。Objective: To prepare the compound ornidazole gargle and determine its contents. Method: Dual wavelength spectro-photomrtry was used to determine ornidazole at 317 nm. The content of chlorhexidine acetate was determined at 247 nm and 278 nm. Result: The average recoveries of ornidazole and chlorhexidine acetate were 99.66% ( RSD =0.40% ) and 100.21% ( RSD = 0. 84% ) ,respectively. Conclusion: The preparing method is simple and the quality control is accurate.

关 键 词：奥硝唑含漱液 复方 制备 分光光度法 

分 类 号：R974[医药卫生—药品]